慢性创伤性脑病:诊断的更新和进展。

IF 3.1 Q2 NEUROSCIENCES

AIMS Neuroscience Pub Date : 2022-01-01 DOI:10.3934/Neuroscience.2022030

Kevin Pierre, Vanessa Molina, Shil Shukla, Anthony Avila, Nicholas Fong, Jessica Nguyen, Brandon Lucke-Wold

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引用次数: 2

摘要

慢性创伤性脑病(CTE)是一种继发于重复性轻度创伤性脑损伤的进行性神经退行性疾病。目前的临床诊断依赖于症状学和结构影像学的发现，这些发现在患有这种疾病的人之间往往差异很大。诊断的金标准是死后病理检查。本文就CTE的概况、诊断方法及影像学和液体生物标志物诊断技术的研究前景作一综述。成像方面，我们讨论了定量结构分析、DTI、fMRI、MRS、SWI和PET CT。对于流体生物标志物，我们讨论了p-tau、TREM2、CCL11、NfL和GFAP。

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Chronic traumatic encephalopathy: Diagnostic updates and advances.

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that occurs secondary to repetitive mild traumatic brain injury. Current clinical diagnosis relies on symptomatology and structural imaging findings which often vary widely among those with the disease. The gold standard of diagnosis is post-mortem pathological examination. In this review article, we provide a brief introduction to CTE, current diagnostic workup and the promising research on imaging and fluid biomarker diagnostic techniques. For imaging, we discuss quantitative structural analyses, DTI, fMRI, MRS, SWI and PET CT. For fluid biomarkers, we discuss p-tau, TREM2, CCL11, NfL and GFAP.

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来源期刊

AIMS Neuroscience NEUROSCIENCES-

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.