细胞因子和活性氧在大脑衰老中的作用。

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI:10.1016/j.mad.2023.111855

Sheba M.J. MohanKumar, Abarna Murugan, Arunkumar Palaniyappan, Puliyur S. MohanKumar

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引用次数: 1

摘要

衰老是一个对大脑产生深远影响的复杂过程。尽管许多外部因素可以促进大脑衰老的开始和进展，但随着时间的推移，外周和中枢免疫细胞的变化也起着重要作用。免疫衰老是一种与年龄相关的免疫功能下降，炎症是衰老大脑中的一种低度炎症状态，有助于细胞因子和活性氧的产生。在这篇综述中，我们重点关注这两种现象在大脑中建立的促炎状态，以及由此导致的大脑结构、功能和修复的有害变化，这些变化导致中枢和神经内分泌功能下降。

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Role of cytokines and reactive oxygen species in brain aging

Aging is a complex process that produces profound effects on the brain. Although a number of external factors can promote the initiation and progression of brain aging, peripheral and central changes in the immune cells with time, also play an important role. Immunosenescence, which is an age-associated decline in immune function and Inflammaging, a low-grade inflammatory state in the aging brain contribute to an elevation in cytokine and reactive oxygen species production. In this review, we focus on the pro-inflammatory state that is established in the brain as a consequence of these two phenomena and the resulting detrimental changes in brain structure, function and repair that lead to a decline in central and neuroendocrine function.

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.