骨形态发生蛋白-2(BMP-2)对动物模型中种植体周围缺损体积和组织测量结果的影响:系统综述和荟萃分析。

IF 1.7 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Eric Lee, Alyssa Moy, Trung Nguyen, Richard Kao, Guo-Hao Lin
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引用次数: 0

摘要

目的:在动物模型中研究BMP-2对种植体周围缺损治疗中体积和组织学变化的影响。材料和方法:对四个数据库进行电子搜索,并在同行评审期刊上手动搜索相关文章。包括动物研究,其数据比较了使用和不使用BMP-2治疗种植体周围缺损的体积和/或组织学结果。进行荟萃分析以分析记录变量的加权平均差(WMD)和置信区间(CI)。结果:完成检索过程后,纳入了21项随机对照试验。荟萃分析结果显示,随访4至8周和12至24周的骨-植入物接触的WMD(%BIC)分别为15.50%(95%CI=3.28%至27.72%,P=0.001)和16.17%(95%CI=111.17%至21.16%,P<0.0001),有利于BMP-2组。随访4至8周和12至24周时,缺损填充百分比的WMD分别为15.88%(95%CI=3.90%至27.86%,P=0.009)和10.48%(95%CI=0.95%至20.02%,P=0.03),有利于BMP-2组。随访8-16周的垂直骨增重的WMD为1.63 mm(95%CI=0.58至2.67 mm,P=0.002),也有利于BMP-2组。结论:本综述表明,在动物模型中,使用BMP-2治疗种植体周围缺陷比未使用BMP-2处理的缺陷显示出更好的临床和组织学结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Bone Morphogenetic Protein-2 (BMP-2) on Volumetric and Histometric Outcomes for Peri-Implant Defects in the Animal Model: A Systematic Review and Meta-Analysis.

Purpose: To study the effect of BMP-2 on the volumetric and histometric changes in peri-implant defect treatments in animal models. Materials and Methods: An electronic search of four databases and a manual search of peer-reviewed journals for relevant articles were performed. Animal studies with data that compared the volumetric and/or histometric outcomes of peri-implant defect treatment with and without the use of BMP-2 were included. Meta-analyses were performed to analyze the weighted mean difference (WMD) and confidence interval (CI) for the recorded variables. Results: After completing the search process, 21 randomized controlled trials were included. The results of the meta-analyses showed that the WMD of bone-to-implant contact (%BIC) with 4 to 8 weeks and 12 to 24 weeks of follow-up was 15.50% (95% CI = 3.28% to 27.72%, P = .01) and 16.17% (95% CI = 11.17% to 21.16%, P < .00001), respectively, favoring the BMP-2 group. The WMD for the percentage of defect fill with 4 to 8 weeks and 12 to 24 weeks of follow-up was 15.88% (95% CI = 3.90% to 27.86%, P = .009) and 10.48% (95% CI = 0.95% to 20.02%, P = .03), respectively, favoring the BMP-2 group. The WMD for the vertical bone gain with 8 to 16 weeks of follow-up was 1.63 mm (95% CI = 0.58 to 2.67 mm, P = .002), also favoring the BMP-2 group. Conclusion: This review demonstrated that the use of BMP-2 in treating peri-implant defects showed better clinical and histometric outcomes than defects not treated with BMP-2 in animal models.

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来源期刊
CiteScore
3.30
自引率
5.00%
发文量
115
审稿时长
6 months
期刊介绍: Edited by Steven E. Eckert, DDS, MS ISSN (Print): 0882-2786 ISSN (Online): 1942-4434 This highly regarded, often-cited journal integrates clinical and scientific data to improve methods and results of oral and maxillofacial implant therapy. It presents pioneering research, technology, clinical applications, reviews of the literature, seminal studies, emerging technology, position papers, and consensus studies, as well as the many clinical and therapeutic innovations that ensue as a result of these efforts. The editorial board is composed of recognized opinion leaders in their respective areas of expertise and reflects the international reach of the journal. Under their leadership, JOMI maintains its strong scientific integrity while expanding its influence within the field of implant dentistry. JOMI’s popular regular feature "Thematic Abstract Review" presents a review of abstracts of recently published articles on a specific topical area of interest each issue.
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