Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya
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The present review was conducted to provide a critical review of the comprehensive and current knowledge regarding <i>C. arvensis</i> species, in particular, its taxonomy and geographical distribution, botanical description, medicinal uses, phytochemical compounds, pharmacological properties, and toxicity investigations. The data collected on <i>C. arvensis</i> were obtained using different scientific research databases such as PubMed, SciFinder, SpringerLink, Web of Science, Science Direct, Google Scholar, Wiley Online, and Scopus. Phytochemical screening of different <i>C. arvensis</i> extracts and essential oils showed their richness in bioactive compounds, particularly in fatty acids, sterols, phenolics, flavonoids, saponins, tannins, alkaloids, and terpenoid compounds. The findings of this review showed that the pharmacological activities of <i>C. arvensis</i> confirm its importance and diversity as a traditional remedy for many diseases. This plant presents a wide range of bioactivities, namely, anti-inflammatory, antimicrobial, antitrypanosomial, antitumoral, antimutagenic, and immunomodulatory activities, as well as hemolytic properties and wound treatment. 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引用次数: 0
摘要
金盏花(菊科)是一种著名的观赏和药用植物,广泛分布于地中海国家和欧洲南部地区。该物种在传统医学中被广泛用于治疗多种疾病,具有多种生物活性,尤其是抗炎、抗病毒、抗突变、抗菌、杀虫、抗氧化和免疫调节活性。本综述旨在对有关 C. arvensis 物种的全面和现有知识,特别是其分类和地理分布、植物学描述、药用、植物化学成分、药理特性和毒性研究进行批判性综述。有关 C. arvensis 的数据是通过不同的科研数据库获得的,如 PubMed、SciFinder、SpringerLink、Web of Science、Science Direct、Google Scholar、Wiley Online 和 Scopus。对不同的 C. arvensis 提取物和精油进行的植物化学筛选表明,它们富含生物活性化合物,尤其是脂肪酸、甾醇、酚类、黄酮类、皂甙、单宁、生物碱和萜类化合物。本综述的研究结果表明,C. arvensis 的药理活性证实了其作为治疗多种疾病的传统疗法的重要性和多样性。这种植物具有广泛的生物活性,即抗炎、抗菌、抗锥虫病、抗肿瘤、抗突变和免疫调节活性,以及溶血和伤口治疗特性。不过,今后的临床试验还需要进行药代动力学验证和毒理学检查,以检测任何可能的毒性。
Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review.
Calendula arvensis L. (Asteraceae) is a famous ornamental and medicinal plant widely distributed in Mediterranean countries and the southern region of Europe. This reputed species is widely used in traditional medicine in the treatment of many disorders and has various bioactivities, especially anti-inflammatory, antiviral, antimutagenic, antimicrobial, insecticidal, antioxidant, and immunomodulatory activities. The present review was conducted to provide a critical review of the comprehensive and current knowledge regarding C. arvensis species, in particular, its taxonomy and geographical distribution, botanical description, medicinal uses, phytochemical compounds, pharmacological properties, and toxicity investigations. The data collected on C. arvensis were obtained using different scientific research databases such as PubMed, SciFinder, SpringerLink, Web of Science, Science Direct, Google Scholar, Wiley Online, and Scopus. Phytochemical screening of different C. arvensis extracts and essential oils showed their richness in bioactive compounds, particularly in fatty acids, sterols, phenolics, flavonoids, saponins, tannins, alkaloids, and terpenoid compounds. The findings of this review showed that the pharmacological activities of C. arvensis confirm its importance and diversity as a traditional remedy for many diseases. This plant presents a wide range of bioactivities, namely, anti-inflammatory, antimicrobial, antitrypanosomial, antitumoral, antimutagenic, and immunomodulatory activities, as well as hemolytic properties and wound treatment. Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.