偏头痛的发生和功能。

IF 5.5 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
FEBS Journal Pub Date : 2022-11-01 DOI:10.1111/febs.16183
Shunbang Yu, Li Yu
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引用次数: 32

摘要

迁移体是一种新发现的由迁移细胞产生的细胞器。当细胞迁移时,在它们的尾迹中会留下又长又细的收缩纤维。在这些纤维上,我们发现了一种类似石榴的结构,我们将其命名为迁移体。迁移体的产生与细胞的迁移高度相关。目前,已经证明迁移体表现出三种作用模式:通过破裂或泄漏释放信号分子,受损线粒体的载体,mRNA或蛋白质的横向转移。在这篇综述中,我们将详细讨论这种新发现的细胞器的功能、机制和潜在的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Migrasome biogenesis and functions.

Migrasome biogenesis and functions.

Migrasome biogenesis and functions.

Migrasome biogenesis and functions.

The migrasome is a newly discovered organelle produced by migrating cells. As cells migrate, long and thin retraction fibers are left in their wake. On these fibers, we discovered the production of a pomegranate-like structure, which we named migrasomes. The production of migrasomes is highly correlated with the migration of cells. Currently, it has been demonstrated the migrasomes exhibit three modes of action: release of signaling molecules through rupturing or leaking, carriers of damaged mitochondria, and lateral transfer of mRNA or proteins. In this review, we would like to discuss, in detail, the functions, mechanisms, and potential applications of this newly discovered cell organelle.

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来源期刊
FEBS Journal
FEBS Journal 生物-生化与分子生物学
CiteScore
11.70
自引率
1.90%
发文量
375
审稿时长
1 months
期刊介绍: The FEBS Journal is an international journal devoted to the rapid publication of full-length papers covering a wide range of topics in any area of the molecular life sciences. The criteria for acceptance are originality and high quality research, which will provide novel perspectives in a specific area of research, and will be of interest to our broad readership. The journal does not accept papers that describe the expression of specific genes and proteins or test the effect of a drug or reagent, without presenting any biological significance. Papers describing bioinformatics, modelling or structural studies of specific systems or molecules should include experimental data.
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