Margot Guth, Marie Lefevre, Corinne Pilorget, Astrid Coste, Shukrullah Ahmadi, Aurélie Danjou, Brigitte Dananché, Delphine Praud, Isabelle Koscinski, Aline Papaxanthos, Oxana Blagosklonov, Patricia Fauque, Olivia Pérol, Joachim Schüz, Louis Bujan, Ann Olsson, Béatrice Fervers, Barbara Charbotel
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The aim of this study was to examine the association between parental occupational exposure to solvents and TGCT risk among their offspring.</p><p><strong>Methods: </strong>A French nationwide case-control study, TESTIS included 454 TGCT cases and 670 controls frequency-matched on region and 5-year age strata. Participants were interviewed via telephone and provided information on parental occupations at birth. Job-exposure matrices (JEM) developed in the French Matgéné program were used to assign exposure to five petroleum-based solvents, five solvents or groups of oxygenated solvents, and five chlorinated solvents. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors.</p><p><strong>Results: </strong>Occupational exposure to at least one solvent during the year of their son's birth was 41% among fathers and 21% among mothers. Paternal exposure to at least one solvent showed OR 0.89 (95% CI 0.68-1.15). Exposure to perchloroethylene (OR 1.41, 95% CI 0.55-3.61), methylene chloride (OR 1.13, 95% CI 0.54-2.34) and diesel/kerosene/fuel oil (OR 1.17, 95% CI 0.80-1.73) disclosed OR >1 but with low precision. Our results suggest a possible modest increase in non-seminoma risk for sons whose fathers were highly exposed to trichloroethylene (OR 1.44, 95% CI 0.79-2.63). Maternal exposure to at least one solvent showed OR 0.90 (95% CI 0.65-1.24). When stratifying by birth year, men born in the 1970s experienced an increased TGCT risk following maternal exposure to fuels and petroleum-based solvents (OR 2.74, 95% CI 1.11-6.76).</p><p><strong>Conclusion: </strong>Overall, no solid association was found between parental occupational exposure to solvents and TGCT risk. The association found with maternal occupational exposure to fuels and petroleum solvents among older men needs further investigation.</p>","PeriodicalId":21528,"journal":{"name":"Scandinavian journal of work, environment & health","volume":"49 6","pages":"405-418"},"PeriodicalIF":4.7000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10812531/pdf/","citationCount":"0","resultStr":"{\"title\":\"Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study).\",\"authors\":\"Margot Guth, Marie Lefevre, Corinne Pilorget, Astrid Coste, Shukrullah Ahmadi, Aurélie Danjou, Brigitte Dananché, Delphine Praud, Isabelle Koscinski, Aline Papaxanthos, Oxana Blagosklonov, Patricia Fauque, Olivia Pérol, Joachim Schüz, Louis Bujan, Ann Olsson, Béatrice Fervers, Barbara Charbotel\",\"doi\":\"10.5271/sjweh.4102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the association between parental occupational exposure to solvents and TGCT risk among their offspring.</p><p><strong>Methods: </strong>A French nationwide case-control study, TESTIS included 454 TGCT cases and 670 controls frequency-matched on region and 5-year age strata. Participants were interviewed via telephone and provided information on parental occupations at birth. Job-exposure matrices (JEM) developed in the French Matgéné program were used to assign exposure to five petroleum-based solvents, five solvents or groups of oxygenated solvents, and five chlorinated solvents. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors.</p><p><strong>Results: </strong>Occupational exposure to at least one solvent during the year of their son's birth was 41% among fathers and 21% among mothers. Paternal exposure to at least one solvent showed OR 0.89 (95% CI 0.68-1.15). Exposure to perchloroethylene (OR 1.41, 95% CI 0.55-3.61), methylene chloride (OR 1.13, 95% CI 0.54-2.34) and diesel/kerosene/fuel oil (OR 1.17, 95% CI 0.80-1.73) disclosed OR >1 but with low precision. Our results suggest a possible modest increase in non-seminoma risk for sons whose fathers were highly exposed to trichloroethylene (OR 1.44, 95% CI 0.79-2.63). Maternal exposure to at least one solvent showed OR 0.90 (95% CI 0.65-1.24). 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引用次数: 0
摘要
目的：睾丸生殖细胞瘤（TGCT）的病因被怀疑与产前环境风险因素有关。某些溶剂具有潜在的内分泌干扰或致癌特性，可能会破坏子宫内男性生殖器的发育。本研究旨在探讨父母职业性接触溶剂与后代患 TGCT 风险之间的关系：TESTIS是一项法国全国范围的病例对照研究，共纳入454例TGCT病例和670例对照，根据地区和5岁年龄层进行频率匹配。研究人员通过电话对参与者进行了访谈，并提供了父母出生时的职业信息。法国 Matgéné 计划开发的职业暴露矩阵 (JEM) 用于分配五种石油溶剂、五种溶剂或含氧溶剂组和五种氯化溶剂的暴露情况。采用条件逻辑回归法估算了TGCT的风险比（OR）和95%置信区间（CI），并对TGCT风险因素进行了调整：在儿子出生当年至少接触过一种溶剂的父亲占 41%，母亲占 21%。父亲接触至少一种溶剂的 OR 值为 0.89（95% CI 为 0.68-1.15）。暴露于四氯乙烯（OR 1.41，95% CI 0.55-3.61）、二氯甲烷（OR 1.13，95% CI 0.54-2.34）和柴油/煤油/燃料油（OR 1.17，95% CI 0.80-1.73）显示 OR >1，但精确度较低。我们的研究结果表明，父亲高度暴露于三氯乙烯（OR 1.44，95% CI 0.79-2.63）的儿子的非血吸虫病风险可能略有增加。母亲至少接触一种溶剂的结果显示 OR 为 0.90（95% CI 为 0.65-1.24）。如果按出生年份进行分层，20 世纪 70 年代出生的男性在母亲接触燃料和石油类溶剂后，患 TGCT 的风险会增加（OR 2.74，95% CI 1.11-6.76）：总体而言，在父母职业性接触溶剂与 TGCT 风险之间没有发现确凿的联系。在老年男性中发现的与母亲职业性接触燃料和石油溶剂有关的关联还需要进一步研究。
Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study).
Objectives: The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the association between parental occupational exposure to solvents and TGCT risk among their offspring.
Methods: A French nationwide case-control study, TESTIS included 454 TGCT cases and 670 controls frequency-matched on region and 5-year age strata. Participants were interviewed via telephone and provided information on parental occupations at birth. Job-exposure matrices (JEM) developed in the French Matgéné program were used to assign exposure to five petroleum-based solvents, five solvents or groups of oxygenated solvents, and five chlorinated solvents. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors.
Results: Occupational exposure to at least one solvent during the year of their son's birth was 41% among fathers and 21% among mothers. Paternal exposure to at least one solvent showed OR 0.89 (95% CI 0.68-1.15). Exposure to perchloroethylene (OR 1.41, 95% CI 0.55-3.61), methylene chloride (OR 1.13, 95% CI 0.54-2.34) and diesel/kerosene/fuel oil (OR 1.17, 95% CI 0.80-1.73) disclosed OR >1 but with low precision. Our results suggest a possible modest increase in non-seminoma risk for sons whose fathers were highly exposed to trichloroethylene (OR 1.44, 95% CI 0.79-2.63). Maternal exposure to at least one solvent showed OR 0.90 (95% CI 0.65-1.24). When stratifying by birth year, men born in the 1970s experienced an increased TGCT risk following maternal exposure to fuels and petroleum-based solvents (OR 2.74, 95% CI 1.11-6.76).
Conclusion: Overall, no solid association was found between parental occupational exposure to solvents and TGCT risk. The association found with maternal occupational exposure to fuels and petroleum solvents among older men needs further investigation.
期刊介绍：
The aim of the Journal is to promote research in the fields of occupational and environmental health and safety and to increase knowledge through the publication of original research articles, systematic reviews, and other information of high interest. Areas of interest include occupational and environmental epidemiology, occupational and environmental medicine, psychosocial factors at work, physical work load, physical activity work-related mental and musculoskeletal problems, aging, work ability and return to work, working hours and health, occupational hygiene and toxicology, work safety and injury epidemiology as well as occupational health services. In addition to observational studies, quasi-experimental and intervention studies are welcome as well as methodological papers, occupational cohort profiles, and studies associated with economic evaluation. The Journal also publishes short communications, case reports, commentaries, discussion papers, clinical questions, consensus reports, meeting reports, other reports, book reviews, news, and announcements (jobs, courses, events etc).
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