聚l -鸟氨酸胆汁酸纳米水凝胶对细胞生物活性的影响及其潜在的药理应用。

IF 3 Q2 PHARMACOLOGY & PHARMACY

Therapeutic delivery Pub Date : 2023-09-05 DOI:10.4155/tde-2023-0034

Bozica Kovacevic, Melissa Jones, Susbin Raj Wagle, Corina Mihaela Ionescu, Thomas Foster, Maja Đanić, Momir Mikov, Armin Mooranian, Hani Al-Salami

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引用次数: 0

摘要

目的:细胞生物活性和与慢性疾病相关的病理生理变化被认为是开发用于生物医学应用的新配方时关键的有害因素。方法:本文研究了胆汁酸和合成多肽聚l -鸟氨酸(PLO)在制剂中的使用及其对多种细胞系的影响，特别关注了它们的细胞生物活性。结果:肝细胞系受PLO的负面影响最大，而肌肉和β -胰腺细胞系对PLO的细胞活力没有明显的负面影响。PLO对肌肉细胞和β细胞的线粒体功能破坏最小。结论:胆汁酸的添加普遍降低了线粒体呼吸，改变了所有细胞系的生物能量参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Influence of poly-L-ornithine-bile acid nano hydrogels on cellular bioactivity and potential pharmacological applications.

Aim: Cellular bioactivity and pathophysiological changes associated with chronic disorders are considered pivotal detrimental factors when developing novel formulations for biomedical applications. Methods: This paper investigates the use of bile acids and synthetic polypeptide poly-L-ornithine (PLO) in formulations and their impacts on a variety of cell lines, with a particular focus on their cellular bioactivity. Results: The hepatic cell line was the most negatively affected by the presence of PLO, while the muscle and beta-pancreatic cell lines did not show as profound of a negative impact of PLO on cellular viability. PLO was the least disruptive regarding mitochondrial function for muscle and beta cells. Conclusion: The addition of bile acids generally decreased mitochondrial respiration and altered bioenergetic parameters in all cell lines.

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来源期刊

Therapeutic delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.