有效的BECN2-ATG14螺旋线圈相互作用对于GPASP1/GASP1相关GPCR的内溶酶体降解是选择性关键的。

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2023-11-01 Epub Date: 2023-07-13 DOI:10.1080/15548627.2023.2233872

Xianxiu Qiu, Na Li, Qifan Yang, Shuai Wu, Xiaohua Li, Xuehua Pan, Soh Yamamoto, Xiaozhe Zhang, Jincheng Zeng, Jiahao Liao, Congcong He, Renxiao Wang, Yanxiang Zhao

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引用次数: 0

摘要

缩写：AMBRA1自噬和beclin 1调节因子1；ATG14自噬相关14；ATG5自噬相关5；ATG7自噬相关7；BECN1 beclin 1；BECN2-beclin2；CC线圈；CQ-氯喹CNR1/CB1R大麻素受体1 DAPI 4’，6-二脒基-2-苯基吲哚；dCCD删除CCD；DRD2/D2R多巴胺受体D2-GPRSP1/GAP1蛋白偶联受体相关分选蛋白1 GPCR G蛋白偶联受体；ITC等温滴定量热法；IP免疫沉淀；KD击倒；KO淘汰赛；MAP1LC3/LC3微管相关蛋白1轻链3；NRBF2核受体结合因子2；OPRD1/DOR阿片受体δ1 PIK3C3/VPS34磷脂酰肌醇3-激酶催化亚基3型；PIK3R4/VPS15磷酸肌醇-3-激酶调节亚单位4；PtdIns3K III类磷脂酰肌醇3-激酶；PtdIns3P磷脂酰肌醇-3-磷酸；RUBCN rubicon自噬调节因子；SQSTM1/p62螯合体1；UVRAG紫外线辐射抗性相关；VPS液泡蛋白分选；WT野生型。

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The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs.

Abbreviations: AMBRA1 autophagy and beclin 1 regulator 1; ATG14 autophagy related 14; ATG5 autophagy related 5; ATG7 autophagy related 7; BECN1 beclin 1; BECN2 beclin 2; CC coiled-coil; CQ chloroquine CNR1/CB1R cannabinoid receptor 1 DAPI 4',6-diamidino-2-phenylindole; dCCD delete CCD; DRD2/D2R dopamine receptor D2 GPRASP1/GASP1 G protein-coupled receptor associated sorting protein 1 GPCR G-protein coupled receptor; ITC isothermal titration calorimetry; IP immunoprecipitation; KD knockdown; KO knockout; MAP1LC3/LC3 microtubule associated protein 1 light chain 3; NRBF2 nuclear receptor binding factor 2; OPRD1/DOR opioid receptor delta 1 PIK3C3/VPS34 phosphatidylinositol 3-kinase catalytic subunit type 3; PIK3R4/VPS15 phosphoinositide-3-kinase regulatory subunit 4; PtdIns3K class III phosphatidylinositol 3-kinase; PtdIns3P phosphatidylinositol-3-phosphate; RUBCN rubicon autophagy regulator; SQSTM1/p62 sequestosome 1; UVRAG UV radiation resistance associated; VPS vacuolar protein sorting; WT wild type.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.