富马酸二甲酯治疗多发性硬化症与脱发相关。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL

Wiener medizinische Wochenschrift Pub Date : 2023-09-01 DOI:10.1007/s10354-023-01007-7

Ana Abičić, Ivan Adamec, Mario Habek

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引用次数: 1

摘要

治疗2周后，一名多发性硬化症患者接受富马酸二甲酯治疗后出现脱发。考虑到不良事件，停止治疗，导致在接下来的3个月内脱发消退。虽然确切的机制尚未完全阐明，谷胱甘肽耗竭或有氧糖酵解下调被认为是诱导脱发的潜在原因。这种罕见的富马酸二甲酯不良反应的发生率和机制有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alopecia associated with dimethyl fumarate treatment for multiple sclerosis.

After 2 weeks of treatment, a woman with multiple sclerosis treated with dimethyl fumarate developed alopecia. Considering the adverse events, the therapy was discontinued, leading to alopecia regression during the next 3 months. Although the precise mechanism has not been completely elucidated, glutathione depletion or downregulation of aerobic glycolysis are considered to be potential reasons for hair loss induction. The incidence and mechanism of this uncommon adverse reaction to dimethyl fumarate should be further investigated.

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来源期刊

Wiener medizinische Wochenschrift MEDICINE, GENERAL & INTERNAL-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： ''From the microscope to clinical application!'', Scientists from all European countries make available their recent research results and practical experience through Wiener Medizinische Wochenschrift, the renowned English- and German-language forum. Both original articles and reviews on a broad spectrum of clinical and preclinical medicine are presented within the successful framework of thematic issues compiled by guest editors. Selected cutting-edge topics, such as dementia, geriatric oncology, Helicobacter pylori and phytomedicine make the journal a mandatory source of information.