Meenu Chaudhary, Sanjeeta Sitaula, Kevin Ruder, Cindi Chen, Lina Zhong, Yu Heng Lu, Thomas Abraham, Danny Yu, Armin Hinterwirth, Thomas M Lietman, Thuy Doan, Gerami D Seitzman
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引用次数: 0
摘要
背景：感染性结膜炎在尼泊尔很常见：材料与方法：这项前瞻性研究从尼泊尔加德满都的柯伊拉腊狮子眼科研究中心（B.P. Koirala Lions Center for Ophthalmic Studies）招募了60名推测患有急性传染性结膜炎的患者。对结膜和前鼻孔的拭子进行处理，以进行元基因组 RNA 深度测序（RNA-seq）：结果：55%的病例确定了病原体。RNA病毒是最常见的病原体。严重急性呼吸系统综合征冠状病毒 2 是最常见的 RNA 病毒：结论：急性传染性结膜炎因地区而异。与预期相反，RNA 病毒占主导地位。重复监测可能有用，RNA-seq 可以检测包括 RNA 病毒在内的意外病原体。
Heterogenous pathogen profile associated with acute conjunctivitis in Nepal.
Background: Infectious conjunctivitis is common in Nepal.
Materials and methods: This prospective study recruited 60 patients with presumed acute infectious conjunctivitis from the B.P. Koirala Lions Center for Ophthalmic Studies in Kathmandu, Nepal. Swabs from the conjunctiva and anterior nares were processed for metagenomic RNA deep sequencing (RNA-seq).
Results: Pathogens were identified in 55% of cases. RNA viruses were the most common pathogen class identified. Severe acute respiratory syndrome coronavirus 2 was the most common RNA virus identified.
Conclusions: Acute infectious conjunctivitis varies by location. Contrary to expectations, RNA viruses predominated. Repeat surveillance may be useful and RNA-seq allows for detection of the unexpected pathogen including RNA viruses.
期刊介绍：
International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions.
It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.
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