评估在新辅助化疗前使用银棒标记肿瘤的经济有效方法

Amr Hossam, Adel El-Badrawy, Ashraf Khater, Ahmed Setit, Sameh Roshdy, Khaled Abdelwahab, Emad Hamed
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摘要

目的:缺乏新辅助化疗(NAC)前肿瘤边缘的客观记录是乳腺癌患者实施安全保乳手术(BCS)的主要制约因素。这项回顾性观察研究采用一种新方法,即用本土银丝标记物标记新辅助化疗前肿瘤边缘,试图通过在标记的新辅助化疗前肿瘤边缘范围内实施切除术来评估乳腺癌患者实施安全保乳手术的可行性:这项回顾性观察研究的对象是 2015 年 5 月至 2022 年 4 月期间在本院肿瘤中心就诊的乳腺癌患者。所有患者都接受了新农合治疗,然后根据多学科团队的建议进行了手术。所有患者均为可手术的原发性单发乳腺癌。在进行新乳腺癌手术前,我们使用银制不透射线金属棒对肿瘤边缘进行定位:结果:共纳入 64 例乳腺癌患者,无一出现与标记物相关的并发症。在 NAC 之后,60 名患者在银质标记物的引导下轻松完成了 BCS,银质标记物被用作临时植入物,并在手术中被移除。只有 2 名患者出现边缘阳性,转为乳房切除术:结论:在开始 NAC 之前使用无菌银标记进行乳腺癌定位是安全、简便、廉价和有效的,不会给患者带来发病率或明显的疼痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Evaluation of a Cost-Effective Method for Tumour Marking Prior to Neo-Adjuvant Chemotherapy Using Silver Rods.

Objective: The lack of objective documentation of pre-neoadjuvant chemotherapy (NAC) tumour margins is a major constraint in performing safe breast conserving surgery (BCS) in patients with breast cancer. Using a novel method of marking pre-NACT tumour margins with indigenous silver wire markers, this retrospective observational study attempted to assess the feasibility of safe BCS in breast cancer patients by performing excision wide of the marked pre-NACT margins.

Materials and methods: This retrospective observational study was conducted on breast cancer patients who were attending our oncology centre between May, 2015 and April, 2022. All patients had received NAC followed by surgery as recommended by our multidisciplinary team. All the patients had a primary operable solitary breast cancer. We used radiopaque metallic rods made from silver to localize tumour margins prior to NAC.

Results: Sixty-four breast cancer patients were included; none had marker-related complications. Following NAC, BCS could be easily performed in 60 patients guided by the silver markers, which were used as temporary implants and removed during surgery. Only 2 patients were seen with positive margins and were converted to mastectomy.

Conclusion: Breast cancer localization using sterile silver markers before the initiation of NAC is safe, easy, inexpensive, and effective, causing no morbidity or significant pain to the patients.

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