[糖尿病高密度脂蛋白功能失调]。

Q4 Medicine
O N Poteryaeva, I F Usynin
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引用次数: 3

摘要

2型糖尿病(DM2)患者患心血管疾病(CVD)的风险增加2至4倍。增加心血管风险的主要因素之一是血脂异常,包括所有脂蛋白的异常,包括高密度脂蛋白(HDL)。DM2的发展不仅伴随着HDL水平的下降,而且伴随着其结构的显著变化。这导致天然HDL转化为所谓的功能失调或糖尿病性HDL,从而失去其抗动脉粥样硬化、心脏保护、抗炎和抗糖尿病的特性。在控制不良的糖尿病患者中,HDL不仅失去其有益功能,而且还获得了促动脉粥样硬化、促炎症的功能。糖尿病高密度脂蛋白可促进诸如癌细胞增殖、迁移和侵袭增加等不利特性的积累。鉴于HDL除了参与胆固醇转运外,在体内还具有重要的调节功能,我们有理由认为HDL的结构修饰(氧化、糖基化、甘油三酯富集、HDL相关酶丧失等)是糖尿病血管并发症的原因之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

[Dysfunctional high-density lipoproteins in diabetes mellitus].

[Dysfunctional high-density lipoproteins in diabetes mellitus].

The risk of cardiovascular disease (CVD) in persons with type 2 diabetes mellitus (DM2) increases two to four times. One of the main factors increasing cardiovascular risk is dyslipidemia, which includes abnormalities in all lipoproteins, including high-density lipoproteins (HDL). The development of DM2 is accompanied not only by a decrease in the level of HDL, but also by significant changes in their structure. This leads to the transformation of native HDL into so-called dysfunctional or diabetic HDL, which loses their antiatherogenic, cardioprotective, anti-inflammatory and anti-diabetic properties. In poorly controlled diabetes mellitus HDL can not only lose its beneficial functions, but also acquire proatherogenic, proinflammatory ones. Diabetic HDL can contribute to the accumulation of such unfavorable qualities as increased proliferation, migration, and invasion of cancer cells. Given that HDL, in addition to participation in cholesterol transport, performs important regulatory functions in the body, there is reason to assume that structural modifications of HDL (oxidation, glycation, triglyceride enrichment, loss of HDL-associated enzymes, etc.) are one of the causes of vascular complications of diabetes.

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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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