子节：基因组变异的热点。

IF 1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & genetic systems Pub Date : 2023-09-30 Epub Date: 2023-08-30 DOI:10.1266/ggs.23-00049

Junko Kanoh

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引用次数: 0

摘要

真核细胞含有多种类型的重复序列。典型的例子是串联重复序列，包括端粒、着丝粒、rDNA基因和转座元件。这些序列大多是不稳定的；因此，它们的拷贝数或序列在进化过程中变化迅速。在这篇综述中，我将描述位于染色体末端端粒附近的亚端粒区域的作用，以及最近关于其序列变异的发现。

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Subtelomeres: hotspots of genome variation.

Eukaryotic cells contain multiple types of duplicated sequences. Typical examples are tandem repeat sequences including telomeres, centromeres, rDNA genes and transposable elements. Most of these sequences are unstable; thus, their copy numbers or sequences change rapidly in the course of evolution. In this review, I will describe roles of subtelomere regions, which are located adjacent to telomeres at chromosome ends, and recent discoveries about their sequence variation.

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