比较 OK-432 和滑石粉浆对肺切除术后长期漏气患者进行胸膜穿刺的疗效。

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Tomohiro Watanabe, Yoshikane Yamauchi, Ryo Takeyama, Shinya Kohmaru, Hitoshi Dejima, Yuichi Saito, Yukinori Sakao
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引用次数: 0

摘要

目的:长期漏气(PAL)是肺切除术后常见的并发症之一。本研究旨在评估使用无菌滑石粉或 OK-432 进行胸膜腔穿刺治疗术后漏气的有效性和安全性:方法:从病历资料中回顾性地找出术后气漏并接受无菌滑石粉或 OK-432 化学胸膜腔穿刺术的患者。对于使用这两种药剂的胸膜腔穿刺术,除个人同意外,每个病例都要事先经过医院安全部门的评估和批准:2016年2月至2022年6月期间,39名PAL患者接受了化学胸膜腔穿刺术。其中,24 名患者接受了滑石粉胸膜穿刺术(滑石粉组),15 名患者接受了 OK-432 胸膜穿刺术(OK-432 组)。滑石粉组有 22 名患者(91.7%)在胸膜腔穿刺不到两次后渗漏就消失了,而 OK-432 组有 14 名患者(93.3%)。与滑石粉组相比,OK-432 组胸膜腔穿刺术后白细胞计数、C 反应蛋白浓度和体温明显升高(P 结论:胸膜腔穿刺术后白细胞计数、C 反应蛋白浓度和体温明显升高:使用滑石粉进行胸膜穿刺可能是治疗术后漏气的有效方法。我们的研究结果表明,滑石粉与 OK-432 同样有效,而且导致的全身炎症反应较轻。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparison of the Efficacies of OK-432 and Talc Slurry for Pleurodesis in Patients with Prolonged Air Leak after Pulmonary Resection.

Purpose: A prolonged air leak (PAL) is one of the common postoperative complications of pulmonary resection. The aim of this study was to evaluate the efficacy and safety of pleurodesis with sterile talc or OK-432 for postoperative air leak.

Methods: Patients with postoperative air leak who received chemical pleurodesis using sterile talc or OK-432 were retrospectively identified from medical records data. For pleurodesis with either agent, prior assessment and approval by the hospital safety department were carried out for each case, in addition to individual consent.

Results: Between February 2016 and June 2022, 39 patients had PALs and underwent chemical pleurodesis. Among them, 24 patients received pleurodesis with talc (Talc group) and 15 with OK-432 (OK-432 group). The leak resolved after less than two pleurodesis treatments in 22 patients (91.7%) in the Talc group compared with 14 patients (93.3%) in the OK-432 group. Pleurodesis significantly increased white blood cell counts, C-reactive protein concentration, and body temperature in the OK-432 group compared with that in the Talc group (p <0.001, p = 0.003, and p <0.001, respectively).

Conclusions: Pleurodesis with talc may be an effective treatment option for postoperative air leak. Our findings suggest that talc was as effective as OK-432 and resulted in a milder systemic inflammatory response.

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来源期刊
Annals of Thoracic and Cardiovascular Surgery
Annals of Thoracic and Cardiovascular Surgery CARDIAC & CARDIOVASCULAR SYSTEMS-SURGERY
CiteScore
2.80
自引率
0.00%
发文量
56
审稿时长
4-8 weeks
期刊介绍: Information not localized
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