体内沉积和清除实验的设计。

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
William D Bennett
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引用次数: 0

摘要

设计用于成像放射性标记药物混合物体内沉积的实验对于估计吸入药物传递和评估传递装置的生物等效性是有用的。放射性标记-药物混合物的验证对于确保后续成像反映药物沉积至关重要。伽马衰减校正的应用允许通过二维(2D)成像来估计药物的总体和局部肺沉积。成像方法也可用于测量体内粘膜纤毛清除(MC)功能。这些措施允许评估旨在改善气道疾病中气道分泌物清除的药物的功效。MC率可以通过控制吸入和伽马相机监测含有非渗透性示踪剂的放射性标记气溶胶来测量。虽然体内mcc率反映了纤毛粘膜装置的功能,但它们也依赖于吸入气溶胶的区域沉积模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Design of In Vivo Deposition and Clearance Experiments.

Experiments designed to image in vivo deposition of radiolabel-drug mixtures are useful for estimating inhaled drug delivery and for assessing bioequivalence of delivery devices. Validation of the radiolabel-drug mixture is vital to ensure that subsequent imaging is reflective of drug deposition. Application of gamma attenuation corrections allows both total and regional lung deposition of drug to be estimated by two-dimensional (2D) imaging. Imaging methods are also useful for measuring in vivo mucociliary clearance (MC) function. Such measures allow assessment of the efficacy of drugs designed to improve clearance of airway secretions in airway disease. MC rates can be measured by controlled inhalation and gamma camera monitoring of radiolabeled aerosols containing non-permeating tracers. While in vivo MC rates reflect the function of the mucociliary apparatus, they are also dependent on regional deposition patterns of the inhaled aerosol.

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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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