研究程序对单圈和双圈新西兰大白兔(Oryctolagus cuuniculus)效果的测量方法

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Rosemary V. Santos , Siddhartha Bhatt , Stephen Foote , Donna Church , Ricardo Fernandes , Jan Bernal , Laura Singer
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引用次数: 0

摘要

实验兔的社会住房被鼓励,并被认为是改善动物福利,由于这个物种的社会性质。然而,在常用的实验室笼中,配对和单圈成年雌兔的生理和心血管(CV)效应的比较发表的信息有限。本研究描述了四只雌性新西兰大白兔的心率、收缩压、活动水平、体温的测量和配对方法,这些兔子先前植入了M10心血管遥测装置。数据是在没有社会住房史的单舍兔中收集的,同时在不受干扰的情况下,在约束、肌肉注射和静脉采血期间。然后,同样的动物被放置在兼容的成对中,并被关在传统的阿伦敦笼子里。正如预期的那样,我们发现成对兔子的活动增加,但在体温和CV参数方面没有显著差异。这些数据表明,配对家兔可以用于安全药理学研究,对数据的影响最小,同时支持改善动物福利。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Method of measuring effects of study procedures in single and pair housed New Zealand White rabbits (Oryctolagus cuniculus)

Social housing of laboratory rabbits is encouraged and thought to improve animal welfare due to the social nature of this species. However, there is limited published information comparing the physiologic and cardiovascular (CV) effects of paired and single housed adult female rabbits in commonly used laboratory caging. This study describes measurement of heart rate, systolic blood pressure, activity level, body temperature and pairing methods in four female New Zealand White rabbits that were previously implanted with M10 cardiovascular telemetry devices. Data was collected in single housed rabbits having no history of social housing while they were undisturbed in the home cage, during restraint, intramuscular injections and intravenous blood collection. The same animals were then placed in compatible pairs and housed in conventional Allentown caging. As expected, we found increased activity in paired rabbits but no significant differences in body temperatures, and CV parameters in single and paired rabbits undergoing the same procedures. These data suggest that paired rabbits can be used for safety pharmacology studies with minimal impact to data, while supporting improved animal welfare.

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来源期刊
Journal of pharmacological and toxicological methods
Journal of pharmacological and toxicological methods PHARMACOLOGY & PHARMACY-TOXICOLOGY
CiteScore
3.60
自引率
10.50%
发文量
56
审稿时长
26 days
期刊介绍: Journal of Pharmacological and Toxicological Methods publishes original articles on current methods of investigation used in pharmacology and toxicology. Pharmacology and toxicology are defined in the broadest sense, referring to actions of drugs and chemicals on all living systems. With its international editorial board and noted contributors, Journal of Pharmacological and Toxicological Methods is the leading journal devoted exclusively to experimental procedures used by pharmacologists and toxicologists.
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