肺腺癌切除标本肺动脉中的松散肿瘤细胞:尽管发病率很高,但与存活率无关

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Hans Blaauwgeers, Federica Filipello, Birgit Lissenberg-Witte, Claudio Doglioni, Teodora Radonic, Idris Bahce, Yuko Minami, Andreas Schonau, Julien P L Vincenten, Adrianus A J Smit, Chris Dickhoff, Erik Thunnissen
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引用次数: 0

摘要

背景:在切除的非小细胞肺癌标本的瘤内肺动脉管腔中可发现松散的肿瘤细胞和肿瘤细胞簇。目前尚不清楚这些是否应被视为肿瘤栓子,并因此可预测预后恶化:研究肺动脉腔内肿瘤细胞的性质及其对预后的影响:这项多中心研究包括一项探索性试验研究和一项验证研究,分别来自 3 家机构。在探索性试点研究中,采用苏木精-伊红和细胞角蛋白7(CK7)染色法,对2007年11月至2010年11月期间确诊的原发性腺癌的回顾性肺切除队列中是否存在肿瘤细胞以及血管内间隙中可能存在的其他细胞进行评分。在验证部分,纳入了 2011 年 1 月至 2016 年 12 月间切除的肺腺癌的两个回顾性队列。研究收集了无复发生存期(RFS)和总生存期(OS)数据:在试点研究中,33例患者中有23例(69.7%)存在CK7+血管内细胞,主要是肿瘤细胞。有血管内肿瘤细胞的患者的5年生存率为61%,而没有血管内肿瘤细胞的患者的5年生存率为40%(P = .19)。在验证研究中,70 例患者中有 41 例(58.6%)存在 CK7+ 血管内肿瘤细胞。有血管内肿瘤细胞的患者的5年RFS为80.0%,而无血管内肿瘤细胞的患者为80.6%(P = .52)。5年OS率分别为82.8%和71.6%(P = .16):结论:大多数非小细胞肺癌切除标本中都发现了肺动脉管腔内的松散肿瘤细胞,但它们与较差的RFS或OS无关。因此,它们很可能是一种假象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Loose Tumor Cells in Pulmonary Arteries of Lung Adenocarcinoma Resection Specimens: No Correlation With Survival, Despite High Prevalence.

Context: Loose tumor cells and tumor cell clusters can be recognized in the lumen of intratumoral pulmonary arteries of resected non-small cell lung cancer specimens. It is unclear whether these should be considered tumor-emboli, and as such could predict a worsened prognosis.

Objective: To investigate the nature and prognostic impact of pulmonary artery intraluminal tumor cells.

Design: This multicenter study involved an exploratory pilot study and a validation study from 3 institutions. For the exploratory pilot study, a retrospective pulmonary resection cohort of primary adenocarcinomas, diagnosed between November 2007 and November 2010, were scored for the presence of tumor cells, as well as potentially other cells in the intravascular spaces, using hematoxylin-eosin and cytokeratin 7 (CK7) stains. In the validation part, 2 retrospective cohorts of resected pulmonary adenocarcinomas, between January 2011 and December 2016, were included. Recurrence-free survival (RFS) and overall survival (OS) data were collected.

Results: In the pilot study, CK7+ intravascular cells, mainly tumor cells, were present in 23 of 33 patients (69.7%). The 5-year OS for patients with intravascular tumor cells was 61%, compared with 40% for patients without intravascular tumor cells (P = .19). In the validation study, CK7+ intravascular tumor cells were present in 41 of 70 patients (58.6%). The 5-year RFS for patients with intravascular tumor cells was 80.0%, compared with 80.6% in patients without intravascular tumor cells (P = .52). The 5-year OS rates were, respectively, 82.8% and 71.6% (P = .16).

Conclusions: Loose tumor cells in pulmonary arterial lumina were found in most non-small cell lung cancer resection specimens and were not associated with a worse RFS or OS. Therefore, most probably they represent an artifact.

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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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