使用QuantiFERON-TB Gold Plus检测高松动脉炎中潜伏性结核病的高流行率

IF 1.1 4区 医学 Q4 Medicine
Ana Luisa Souza Pedreira, Rodrigo Pinheiro Leal Costa, Josenor Filipe Pitanga Silva, Mittermayer Barreto Santiago
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引用次数: 0

摘要

目的:本研究旨在利用QuantiFERON-TB Gold Plus方法研究高松动脉炎(TA)患者的潜伏性结核。患者和方法:本病例对照研究纳入22例TA患者(男性3例,女性19例;中位年龄:36.5岁;IQR, 32 ~ 50岁),健康个体22例(男性3例,女性19例;中位年龄:38.5岁;IQR, 32.5 ~ 50岁),弥漫性结缔组织病(DCTDs) 66例(男性4例,女性62例;中位年龄:41岁;IQR, 29.8至54岁)。形成两个对照组:(i)年龄和性别匹配的健康个体和(ii)患有其他DCTDs的患者。收集流行病学资料,并进行QFT-Plus检测。比较各组间QFT-plus阳性率。结果:TA组QFT-Plus阳性检出率(8/22)高于健康对照组(1/22)(p=0.020)和其他DCTDs组(3/66)(p=0.001)。TA组与DCTD组过去肺结核患病率差异有统计学意义(p=0.013)。结论:TA患者的潜伏性结核患病率(36.4%)高于两组对照组,也高于巴西普通人群的潜伏性结核患病率。虽然发现了正相关,但不可能建立直接的因果关系。鉴于抗细胞因子治疗在TA中的使用越来越多,有必要在开始免疫抑制治疗之前彻底筛查TA患者,以避免结核病再激活。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis.

Objectives: This study aims to investigate latent tuberculosis using the QuantiFERON-TB Gold Plus method in patients with Takayasu arteritis (TA).

Patients and methods: This case-control study included 22 patients with TA (3 males, 19 females; median age: 36.5 years; IQR, 32 to 50 years), 22 healthy individuals (3 males, 19 females; median age: 38.5 years; IQR, 32.5 to 50 years), and 66 patients with diffuse connective tissue diseases (DCTDs) (4 males, 62 females; median age: 41 years; IQR, 29.8 to 54 years). Two control groups were formed: (i) age- and sex-matched healthy individuals and (ii) patients with other DCTDs. Epidemiological data were collected, and the QFT-Plus test was performed. The QFT-plus positivity was compared among the groups.

Results: A higher prevalence of QFT-Plus positive cases was observed in the TA group (8/22) than in the healthy control group (1/22) (p=0.020) or in the group with other DCTDs (3/66) (p=0.001). There was a statistically significant difference in the past pulmonary tuberculosis prevalence between the TA and DCTD groups (p=0.013).

Conclusion: The prevalence of latent tuberculosis in TA patients (36.4%) was higher than that in both control groups and higher than the prevalence of latent tuberculosis among the general Brazilian population. Although a positive association was found, it is not possible to establish a direct cause-effect relationship. Given the increasing use of anti-cytokine therapies in TA, it is necessary to thoroughly screen patients with TA before initiating immunosuppressive therapy to avoid tuberculosis reactivation.

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来源期刊
Archives of rheumatology
Archives of rheumatology Medicine-Rheumatology
CiteScore
2.00
自引率
9.10%
发文量
15
期刊介绍: The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).
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