mirna:糖尿病免疫系统的调节因子

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Mutation Research-Reviews in Mutation Research Pub Date : 2022-07-01 DOI:10.1016/j.mrrev.2022.108442

Helaleh Vaezi Heris , Zohreh Zahraei

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引用次数: 0

摘要

糖尿病是最常见的多因素代谢紊乱之一，在世界范围内危害人类健康。MicroRNAs (miRNAs)是一组小的非编码rna，通过转录后机制参与基因表达的调控。mirna的潜在作用已经被研究在包括糖尿病在内的多种疾病进展的大多数生物学过程和机制中。在这篇综述中，我们重点关注mirna在调节与糖尿病疾病进展的免疫系统相关的关键分子和细胞机制中的作用。

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miRNAs: Regulators of immune system in diabetes

Diabetes, one of the most common multifactorial metabolic disorders, is a jeopardizing cause of human health worldwide. MicroRNAs (miRNAs) are a group of small non-coding RNAs that have been contributed to the regulation of gene expression through post-transcriptional mechanisms. The potential role of miRNAs has been studied in the most of biological processes and mechanisms underlying the progression of variety diseases including diabetes. In this review, we focus on the role of miRNAs in regulating pivotal molecular and cellular mechanisms associated with immune system that progress diabetic disorders.

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.