运动能抑制衰老细胞的积累

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2022-10-01 Epub Date: 2022-07-01 DOI:10.1249/JES.0000000000000302

Xu Zhang, Davis A Englund, Zaira Aversa, Sarah K Jachim, Thomas A White, Nathan K LeBrasseur

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引用次数: 0

摘要

我们认为，运动的益处部分是通过预防和消除衰老细胞来实现的。运动可以对抗多种形式的与年龄相关的分子损伤，这些损伤会启动衰老程序，并激活负责清除衰老细胞的免疫细胞。本文讨论了运动作为衰老靶向疗法的临床前和临床证据，以及需要进一步研究的领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Exercise Counters the Age-Related Accumulation of Senescent Cells.

We propose the beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells. Exercise counters multiple forms of age-related molecular damage that initiate the senescence program and activates immune cells responsible for senescent cell clearance. Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.