Sabine Baumgarten, Tabea Hoberg, Tibor Lohmann, Babac Mazinani, Peter Walter, Antonis Koutsonas
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A fullfield pattern-reversal visual evoked potential (FF-PR-VEP) with two stimulus sizes (ss) (20.4' and 1.4°) as well as an extrafoveal pattern onset-offset VEP (EF-P-ON/OFF-VEP) (ss 1.4° and 2.8°) was derived in accordance with the International Society for Clinical Electrophysiology of Vision guidelines. Amplitudes and latencies were recorded, and the mean values as well as standard deviations were calculated. Age- and sex-dependent influences and the difference between phakic and pseudophakic eyes were examined. A subanalysis of EF-P-ON/OFF-VEP and fullfield pattern onset-offset VEP (FF-P-ON/OFF-VEP) was performed. A 55-inch curved OLED display (LG55EC930V, LG Electronics Inc., Seoul, South Korea) was used as visual stimulator.</p><p><strong>Results: </strong>Mean P100 latency of the FF-PR-VEP was 103.81 ± 7.77 ms (ss 20.4') and 102.58 ± 7.26 ms (ss 1.4°), and mean C2 latency of the EF-P-ON/OFF-VEP was 102.95 ± 11.84 ms (ss 1.4°) and 113.58 ± 9.87 ms (ss 2.8°). For all stimulation settings (FF-PR-VEP, EF-P-ON/OFF-VEP), a significant effect of age with longer latencies and smaller amplitudes in older subjects and higher amplitudes in women was observed. We saw no significant difference in latency or amplitude between phakic and pseudophakic eyes and between EF-P-ON/OFF-VEP and FF-P-ON/OFF-VEP.</p><p><strong>Conclusions: </strong>A curved OLED visual stimulator is well suited to obtain VEP response curves with a reasonable interindividual variability. We found significant effects of age and gender in our responses but no effect of the lens status. 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引用次数: 0
摘要
目的:视觉诱发电位(VEP)是多种眼科和神经系统疾病的重要诊断工具。定量反应数据因患者而异，但也依赖于记录和刺激设备。我们为我们的设置建立了VEP参考值，该设置最近通过使用弯曲的OLED显示器作为视觉刺激器进行了修改。区分了全场(FF)和中央凹外(EF)传导，并确定了性别、年龄和晶状体状态的影响。方法:本前瞻性横断面研究纳入162名10岁以上受试者的162只健康眼睛。根据国际临床视觉电生理学会的指南，得出了具有两种刺激大小(ss)(20.4°和1.4°)的全视野模式反转视觉诱发电位(FF-PR-VEP)以及中央凹外模式发作偏移VEP (EF-P-ON/OFF-VEP) (ss 1.4°和2.8°)。记录振幅和潜伏期，并计算平均值和标准差。检查了年龄和性别依赖性影响以及晶状眼和假性晶状眼之间的差异。对EF-P-ON/OFF-VEP和全场模式启动偏移VEP (FF-P-ON/OFF-VEP)进行亚分析。使用55英寸弯曲OLED显示屏(LG55EC930V, LG Electronics Inc.， Seoul, South Korea)作为视觉刺激器。结果:FF-PR-VEP的平均P100潜伏期分别为103.81±7.77 ms (ss 20.4′)和102.58±7.26 ms (ss 1.4°)，EF-P-ON/OFF-VEP的平均C2潜伏期分别为102.95±11.84 ms (ss 1.4°)和113.58±9.87 ms (ss 2.8°)。对于所有刺激设置(FF-PR-VEP, EF-P-ON/OFF-VEP)，年龄的显著影响在老年受试者中观察到较长的潜伏期和较小的振幅，而在女性中观察到较高的振幅。我们观察到有晶态眼和假晶态眼以及EF-P-ON/OFF-VEP和FF-P-ON/OFF-VEP之间的潜伏期和振幅无显著差异。结论:弯曲的OLED视觉刺激器非常适合获得具有合理个体间变异性的VEP反应曲线。我们发现年龄和性别对我们的反应有显著影响，但对隐形眼镜的状态没有影响。EF-P-ON/OFF-VEP倾向于显示较小的振幅。
Fullfield and extrafoveal visual evoked potentials in healthy eyes: reference data for a curved OLED display.
Purpose: Visual evoked potentials (VEP) present an important diagnostic tool in various ophthalmologic and neurologic diseases. Quantitative response data varied among patients but are also dependent on the recording and stimulating equipment. We established VEP reference values for our setting which was recently modified by using a curved OLED display as visual stimulator. Distinction is made between fullfield (FF) and extrafoveal (EF) conduction, and the effect of sex, age and lens status was determined.
Methods: This prospective cross-sectional study included 162 healthy eyes of 162 test persons older than 10 years. A fullfield pattern-reversal visual evoked potential (FF-PR-VEP) with two stimulus sizes (ss) (20.4' and 1.4°) as well as an extrafoveal pattern onset-offset VEP (EF-P-ON/OFF-VEP) (ss 1.4° and 2.8°) was derived in accordance with the International Society for Clinical Electrophysiology of Vision guidelines. Amplitudes and latencies were recorded, and the mean values as well as standard deviations were calculated. Age- and sex-dependent influences and the difference between phakic and pseudophakic eyes were examined. A subanalysis of EF-P-ON/OFF-VEP and fullfield pattern onset-offset VEP (FF-P-ON/OFF-VEP) was performed. A 55-inch curved OLED display (LG55EC930V, LG Electronics Inc., Seoul, South Korea) was used as visual stimulator.
Results: Mean P100 latency of the FF-PR-VEP was 103.81 ± 7.77 ms (ss 20.4') and 102.58 ± 7.26 ms (ss 1.4°), and mean C2 latency of the EF-P-ON/OFF-VEP was 102.95 ± 11.84 ms (ss 1.4°) and 113.58 ± 9.87 ms (ss 2.8°). For all stimulation settings (FF-PR-VEP, EF-P-ON/OFF-VEP), a significant effect of age with longer latencies and smaller amplitudes in older subjects and higher amplitudes in women was observed. We saw no significant difference in latency or amplitude between phakic and pseudophakic eyes and between EF-P-ON/OFF-VEP and FF-P-ON/OFF-VEP.
Conclusions: A curved OLED visual stimulator is well suited to obtain VEP response curves with a reasonable interindividual variability. We found significant effects of age and gender in our responses but no effect of the lens status. EF-P-ON/OFF-VEP tends to show smaller amplitudes.
期刊介绍：
Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).
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