癌症中的中心体功能障碍。

4区生物学 Q3 Medicine

Advances in Anatomy Embryology and Cell Biology Pub Date : 2022-01-01 DOI:10.1007/978-3-031-20848-5_4

Heide Schatten

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引用次数: 0

摘要

由于Theodor Boveri在生殖细胞方面的着丝体研究取得了重大成就和突破，无脊椎动物海胆是研究受精、细胞分裂和胚胎发育的理想模型系统，这些研究也产生了Boveri关于癌细胞的辉煌概念。他发现两个精子受精的卵子会导致三极有丝分裂和异常的细胞分裂，类似于在癌症组织中观察到的细胞。

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Centrosome Dysfunctions in Cancer.

As major accomplishments and breakthroughs in centrosome research had been achieved by Theodor Boveri in reproductive cells with the invertebrate sea urchin being an ideal model system for such studies on fertilization, cell division, and embryo development, these studies also gave rise to Boveri's brilliant concept regarding cancer cells. He discovered that eggs fertilized with two sperm resulted in tripolar mitosis and abnormal cell division, similar to cells observed in cancer tissue.

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来源期刊

Advances in Anatomy Embryology and Cell Biology 生物-发育生物学

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： "Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.