Saliha Selin Özuygur Ermis, Aram Norouzi, Magnus P. Borres, Rani Basna, Linda Ekerljung, Carina Malmhäll, Emma Goksör, Göran Wennergren, Madeleine Rådinger, Jan Lötvall, Hannu Kankaanranta, Bright I. Nwaru
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Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.</p>\n </section>\n </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.12294","citationCount":"0","resultStr":"{\"title\":\"Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander\",\"authors\":\"Saliha Selin Özuygur Ermis, Aram Norouzi, Magnus P. Borres, Rani Basna, Linda Ekerljung, Carina Malmhäll, Emma Goksör, Göran Wennergren, Madeleine Rådinger, Jan Lötvall, Hannu Kankaanranta, Bright I. 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引用次数: 0
摘要
背景分子变态反应学在变态反应性疾病的诊断和治疗中越来越普遍。然而,关于成人猫分子过敏原的数据仍然缺乏。因此,我们旨在揭示猫分子过敏原的致敏模式。方法参与者从瑞典西部哮喘研究中招募,这是一项以人群为基础的研究,纳入了16-75岁的哮喘受试者。1872人中,361人猫皮屑免疫球蛋白E阳性,并进一步分析猫分子过敏原(Fel d 1/2/4/7)。致敏模式分为单致敏、多致敏和伴随致敏,并与人口统计学和临床测量相关。结果猫致敏者中,分泌珠蛋白致敏者占84.2%,脂钙素致敏者占42.4%。近一半的受试者对feld1单敏感。20.2%的患者多致敏,7.2%的患者同时对蛋白家族致敏。哮喘患病率、猫暴露和农村生活与对蛋白质家族的多重及伴随致敏有关。哮喘患者对单一过敏原的同时致敏比非哮喘患者更常见,而对Fel d1和Fel d1的同时致敏是哮喘患者最常见的模式。敏化模式也因养猫和城市化程度而异。结论90.9%的猫致敏受试者对分子过敏原有致敏反应,且因受试者的背景特征和是否存在哮喘而存在差异。鉴定对猫过敏原的致敏模式可以更好地表征猫过敏受试者。
Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander
Background
The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens.
Methods
Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16–75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.
Results
Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.
Conclusion
Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.
期刊介绍:
Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience.
Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.