piwi相互作用rna与人类睾丸功能。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Gülizar Saritas, Ailsa Maria Main, Sofia Boeg Winge, Nina Mørup, Kristian Almstrup
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引用次数: 1

摘要

小非编码RNA (sncRNAs)是长度在200 bp以下的RNA片段,代表了具有许多不同生物学功能的不同RNA群。描述最好的亚型是microrna,其主要功能是转录后基因调控,对大多数生理过程至关重要。对生殖细胞特别感兴趣的是piwi相互作用rna (pirna),这是一类长度为21- 35bp的sncRNA,几乎只存在于生殖细胞中。最近,pirna对睾丸功能至关重要这一点已经变得很清楚,从这个角度来看,我们概述了目前人类pirna的知识。虽然pirna似乎是生殖细胞所特有的,但它们也被描述为各种体细胞癌症和生物液体。在这里,我们讨论了pirna在体细胞组织中的潜在功能,以及在生物体液中的检测是否可以用作睾丸功能的生物标志物。本文分类如下:生殖系统疾病>遗传学/基因组学/表观遗传学生殖系统疾病>分子和细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

PIWI-interacting RNAs and human testicular function.

PIWI-interacting RNAs and human testicular function.

Small noncoding RNAs (sncRNAs) are pieces of RNA with a length below 200 bp and represent a diverse group of RNAs having many different biological functions. The best described subtype is the microRNAs which primarily function in posttranscriptional gene regulation and appear essential for most physiological processes. Of particular interest for the germline is the PIWI-interacting RNAs (piRNAs) which are a class of sncRNA of 21-35 bp in length that are almost exclusively found in germ cells. Recently, it has become clear that piRNAs are essential for testicular function, and in this perspective, we outline the current knowledge of piRNAs in humans. Although piRNAs appear unique to germ cells, they have also been described in various somatic cancers and biofluids. Here, we discuss the potential function of piRNAs in somatic tissues and whether detection in biofluids may be used as a biomarker for testicular function. This article is categorized under: Reproductive System Diseases > Genetics/Genomics/Epigenetics Reproductive System Diseases > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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