Jéssika Aline do Nascimento Medeiros, Ayane Cristine Alves Sarmento, Emanuelly Bernardes-Oliveira, Ronnier de Oliveira, Maysa Eunice Grigorio Bezerra Lima, Ana Katherine Gonçalves, Deyse de Souza Dantas, Janaina Cristiana de Oliveira Crispim
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引用次数: 0
摘要
不同的研究表明，小的非编码rna，如从外泌体获得的microrna (miRNAs)，被认为是几种类型癌症的潜在生物标志物，包括宫颈癌(CC)。因此，本研究旨在概述循环外泌体mirna的作用，这些mirna有可能作为CC的诊断和预后的生物标志物，并根据CC的阶段分析这些mirna的存在。为此，研究人员查阅了2015年至2021年间发表的MEDLINE/PubMed、Scopus和Web of Science电子数据库中的文章。根据入选标准对研究进行筛选后，纳入了7篇文章。除了每篇文章中用于样本分析、检测和分离mirna的方法外，还从所研究的患者中提取了临床数据，如癌症分期。在分析了7个mirna的网络后，它们与免疫系统、CC进展和分期以及顺铂耐药性有关。鉴于mirna在宫颈癌中的研究具有重要的临床意义，我们在此综述中试图总结mirna在宫颈癌中的研究现状和潜在的发展前景。
Evaluation of Exosomal miRNA as Potential Biomarkers in Cervical Cancer.
Different studies show that small non-coding RNAs, such as microRNAs (miRNAs) obtained from exosomes, are considered potential biomarkers in several types of cancer, including cervical cancer (CC). Therefore, the present study seeks to present an overview of the role of circulating exosomal miRNAs with the potential to act as biomarkers for the diagnosis and prognosis of CC and to analyze the presence of these miRNAs according to the stage of CC. For this purpose, a review was developed, with articles consulted from the electronic databases MEDLINE/PubMed, Scopus, and Web of Science published between 2015 and 2021. Seven articles were included after a selection of studies according to the eligibility criteria. In addition to the methods used for sample analysis, detection, and isolation of miRNAs in each article, clinical data were also extracted from the patients studied, such as the stage of cancer. After analyzing the network of the seven miRNAs, they were associated with the immune system, CC progression and staging, and cisplatin resistance. With the belief that studies on miRNAs in cervical cancer would have major clinical implications, in this review, we have attempted to summarize the current situation and potential development prospects.
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