Yeonsoo Kim, Jiyoung Hwang, Sung Hwan Bae, Seong Sook Hong, Yun-Woo Chang, Hyun-Joo Kim, Sang Hyun Kim, So-Young Jin
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引用次数: 0
摘要
摘要:我们旨在探讨横波弥散斜率在减肥手术前评估病态肥胖患者非酒精性脂肪性肝炎(NASH)的临床可行性。这项前瞻性研究收集了2019年2月至2020年12月期间在减肥手术期间接受肝脏活检的25名参与者的数据。所有患者术前均行超声横波弹性成像，测量横波速度和横波弥散斜率。肝脏标本由1名病理学家对非酒精性脂肪性肝病(NAFLD)进行组织学评分。根据组织病理结果比较超声检查结果。使用受试者工作特征曲线下面积(AUC)评估区分NASH和NAFLD的诊断性能。NASH组中位横波速度(1.48 vs 1.62 m/s, P = 0.014)和弥散斜率(8.40 vs 11.80 [m/s]/kHz, P = 0.004)高于NAFLD组。随着活动度(P = 0.032)和肝纤维化程度(P = 0.015)的增加，横波弥散斜率有逐渐增大的趋势。横波色散斜率鉴别NASH与NAFLD的AUC (AUC, 0.83;95%可信区间(0.66-1.00)高于横波速度(AUC, 0.78;95% CI, 0.60-0.97)，但未达到统计学意义(P = 0.729)。横波色散斜率可能是评估病态肥胖患者NASH的可行工具。
Clinical Feasibility of Shear Wave Dispersion Slope for Noninvasive Diagnosis of Nonalcoholic Steatohepatitis in Patients With Morbid Obesity: Preliminary Results Using US Shear Wave Elastography.
Abstract: We aimed to investigate the clinical feasibility of shear wave dispersion slope for assessing nonalcoholic steatohepatitis (NASH) in patients with morbid obesity before bariatric surgery.This prospective study collected data from 25 participants who received liver biopsy during bariatric surgery between February 2019 and December 2020. All participants underwent ultrasonography shear wave elastography before surgery and shear wave speed and shear wave dispersion slope were measured. Liver specimens were evaluated by 1 pathologist scored histologically for nonalcoholic fatty liver disease (NAFLD). Ultrasonography measurements were compared according to histopathologic findings. Diagnostic performance in differentiating NASH from NAFLD was evaluated using the area under the receiver operating characteristic curve (AUC). Median shear wave speed (1.48 vs 1.62 m/s, P = 0.014) and dispersion slope (8.40 vs 11.80 [m/s]/kHz, P = 0.004) were higher in NASH group than in NAFLD group. Shear wave dispersion slope tended to increase step by step as the severity of activity grade (P = 0.032) and hepatic fibrosis (P = 0.015) increased. The AUC of shear wave dispersion slope for differentiating NASH from NAFLD (AUC, 0.83; 95% confidence intervals, 0.66-1.00) was higher than that of shear wave speed (AUC, 0.78; 95% CI, 0.60-0.97), although it did not reach statistical significance (P = 0.729). Shear wave dispersion slope could be a feasible tool for assessing NASH in patients with morbid obesity.
期刊介绍：
Ultrasound Quarterly provides coverage of the newest, most sophisticated ultrasound techniques as well as in-depth analysis of important developments in this dynamic field. The journal publishes reviews of a wide variety of topics including trans-vaginal ultrasonography, detection of fetal anomalies, color Doppler flow imaging, pediatric ultrasonography, and breast sonography.
Official Journal of the Society of Radiologists in Ultrasound
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