白血病干细胞和造血干细胞移植治疗急性髓系白血病的进展:临床试验的叙述性回顾。

Q1 Biochemistry, Genetics and Molecular Biology
Vikram Sumbly, Ian Landry, Christina Sneed, Qamar Iqbal, Anu Verma, Tenzin Dhokhar, Adeel Masood, Akshay Amaraneni
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引用次数: 1

摘要

目的:本文献综述的目的是总结并简要概述我们目前对急性髓性白血病(AML)的理解以及干细胞移植(SCT)在其治疗中的作用。背景:AML是一种恶性血液系统疾病,其特征是髓系血细胞不受控制的增殖。这种疾病与多种危险因素有关,如电离辐射、香烟烟雾、杀虫剂/除草剂和化疗。SCT仍然是医学上适合AML患者的最有益的治疗方法,因为它具有优越的生存结果。方法:采用相关关键词在PubMed、Scopus、ClinicalTrials.gov、Embase和Web of Science上进行全面检索。我们选择了目前关于干细胞治疗在AML患者中的应用的文章。结论:长期暴露于电离辐射及苯、香烟烟雾、化疗药物等有害物质中,在AML的癌变中起重要作用。某些基因(如ASXL1、RUNX1、KIT、TP53、BCR-ABL1)的突变似乎会加速这一过程,因为它们会影响正常的细胞增殖和细胞死亡。这些事件可能导致白血病干细胞(LSC)的一小部分亚群持续维持肿瘤的发展和生长。由于总生存率(OS)提高(~50%)和复发风险降低(32%对59%),医学上认为“适合”的患者应接受同种异体造血干细胞移植(allogenic hematopoietic stem cell transplantation, alloo - hsct)。几项研究表明,医学上“不适合”的人可能会受益于更传统的药物,如阿扎胞苷、地西他滨、维尼托克拉克或索拉非尼。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Leukemic stem cells and advances in hematopoietic stem cell transplantation for acute myeloid leukemia: a narrative review of clinical trials.

Objective: The purpose of this literature review is to summarize and provide a brief overview of our current understanding of acute myeloid leukemia (AML) and the role of stem cell transplantation (SCT) in its management.

Background: AML is a malignant hematological disorder that is characterized by the uncontrolled proliferation of myeloid blood cells. This disease has been associated with various risk factors such as ionizing radiation, cigarette smoke, pesticides/herbicides, and chemotherapy. SCT remains the most beneficial treatment for medically fit AML patients due to superior survival outcomes.

Methods: A thorough search was conducted on PubMed, Scopus, ClinicalTrials.gov, Embase and Web of Science using related keywords. Current articles on the uses of stem cell therapy in AML patients were selected.

Conclusions: Long term exposure to ionizing radiation and other harmful substances such as benzene, cigarette smoke and chemotherapeutic drugs plays an important role in AML carcinogenesis. Mutations in certain genes (e.g., ASXL1, RUNX1, KIT, TP53, BCR-ABL1) seem to accelerate the process as they affect normal cellular proliferation and cell death. These events may give rise to a small subpopulation of leukemic stem cells (LSC) which continuously sustain tumor development and growth. Patients who are deemed to be medically "fit" should receive an allogenic hematopoietic stem cell transplantation (allo-HSCT) due to improved overall survival (OS) (~50%) and decreased relapsed risk (32% vs. 59%). Several studies have revealed that the medically "unfit" may benefit from more conventional agents such as azacytidine, decitabine, venetoclax or sorafenib.

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来源期刊
Stem cell investigation
Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
5.80
自引率
0.00%
发文量
9
期刊介绍: The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.
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