嗜铬细胞瘤和副神经节瘤的核和线粒体DNA改变及其潜在的治疗。

IF 4.1 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Mouna Tabebi, Peter Söderkvist, Oliver Gimm
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引用次数: 1

摘要

线粒体DNA (mtDNA)的改变已在不同类型的癌症中被报道,并被认为在癌症的发生和转移中起重要作用。然而,关于其参与嗜铬细胞瘤和副神经节瘤(PCCs/PGLs)形成的信息很少。PCCs和pgl是肾上腺髓质和肾上腺外副神经节染色质细胞合成和分泌儿茶酚胺的罕见内分泌肿瘤。在过去的30年里,大约60%涉及核DNA改变的PCCs/ pgl的遗传背景已经确定。最近,一项研究表明,在剩余的PCCs/ pgl中,可以发现大约17%的线粒体改变。在这篇综述中,我们总结了最近关于核和线粒体改变及其在PCCs/ pgl中的作用的知识。我们还提供了与PCCs/ pgl和潜在治疗靶点相关的遗传学和分子途径的简要见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nuclear and mitochondrial DNA alterations in pheochromocytomas and paragangliomas, and their potential treatment.

Mitochondrial DNA (mtDNA) alterations have been reported in different types of cancers and are suggested to play important roles in cancer development and metastasis. However, there is little information about its involvement in pheochromocytomas and paragangliomas (PCCs/PGLs) formation. PCCs and PGLs are rare endocrine tumors of the chromaffin cells in the adrenal medulla and extra-adrenal paraganglia that can synthesize and secrete catecholamines. Over the last 3 decades, the genetic background of about 60% of PCCs/PGLs involving nuclear DNA alterations has been determined. Recently, a study showed that mitochondrial alterations can be found in around 17% of the remaining PCCs/PGLs. In this review, we summarize recent knowledge regarding both nuclear and mitochondrial alterations and their involvement in PCCs/PGLs. We also provide brief insights into the genetics and the molecular pathways associated with PCCs/PGLs and potential therapeutical targets.

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来源期刊
Endocrine-related cancer
Endocrine-related cancer 医学-内分泌学与代谢
CiteScore
7.80
自引率
2.60%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Endocrine-Related Cancer is an official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, the United Kingdom and Ireland Neuroendocrine Society, and the Japanese Hormones and Cancer Society. Endocrine-Related Cancer provides a unique international forum for the publication of high quality original articles describing novel, cutting edge basic laboratory, translational and clinical investigations of human health and disease focusing on endocrine neoplasias and hormone-dependent cancers; and for the publication of authoritative review articles in these topics. Endocrine neoplasias include adrenal cortex, breast, multiple endocrine neoplasia, neuroendocrine tumours, ovary, prostate, paraganglioma, parathyroid, pheochromocytoma pituitary, testes, thyroid and hormone-dependent cancers. Neoplasias affecting metabolism and energy production such as bladder, bone, kidney, lung, and head and neck, are also considered.
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