胰岛素抵抗中血氧结合特性的研究。

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2023-04-01 DOI:10.18097/PBMC20236902133

V V Zinchuk, J S O Al-Jebur, N V Glutkina

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引用次数: 0

摘要

研究了男性胰岛素抵抗(IR)患者血氧结合特性。测定静脉血血浆中乳酸蛋白含量、血氧转运功能参数、气体递质、一氧化氮和硫化氢含量。在研究的血asprosin含量升高的IR患者中，注意到血氧功能受损;体重正常的IR患者血红蛋白对氧亲和力增高，而超重和1度肥胖的IR患者血红蛋白对氧亲和力降低。检测到的一氧化氮浓度的增加和硫化氢浓度的减少可能对血液的氧结合特性和代谢失衡的发展很重要。

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Oxygen-binding properties of blood in insulin resistance with different asprosin content.

The oxygen-binding properties of blood were studied in male patients with insulin resistance (IR) with different levels of asprosin. The content of asprosin, parameters of blood oxygen transport function, as well as gas transmitters, nitrogen monoxide and hydrogen sulfide, were determined in the venous blood plasma. In the studied IR patients with increased blood asprosin content, impaired blood oxygenation was noted; IR patients with normal body weight had increased hemoglobin affinity for oxygen, while in IR patients with overweight and the 1st degree obesity, this parameter decreased. The detected increase in the concentration of nitrogen monoxide and the decrease in hydrogen sulfide may be important for the oxygen-binding properties of the blood and the development of metabolic imbalance.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).