猫孢子虫病治疗的进展与挑战

IF 1.5 4区 生物学 Q4 MYCOLOGY
Isabella Dib Ferreira Gremião , Luisa Helena Monteiro de Miranda , Gabriela Reis Pereira-Oliveira , Rodrigo Caldas Menezes , Ana Caroline de Sá Machado , Anderson Messias Rodrigues , Sandro Antonio Pereira
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引用次数: 4

摘要

家猫是最易受孢子丝菌感染的宿主,会出现严重的临床症状。很少有有效的抗真菌药物可用于治疗猫孢子虫病,治疗失败的情况是常见的。治疗成功取决于猫的健康状况、治疗相关因素以及社会/经济问题,但主要取决于宿主-真菌的相互作用。主人的坚持是至关重要的,应该在整个治疗过程中加强,以增加成功结果的机会。针对猫孢子虫病的抗真菌药物最常用于单药治疗方案。由于伊曲康唑治疗失败的病例,应考虑联合使用抗真菌药物以达到协同作用。伊曲康唑联合碘化钾是治疗出现多发性皮肤病变、鼻黏膜病变和/或呼吸症状的naïve猫以及难治性病例的重要选择。然而,治疗失败的病例的治疗选择很少。因此,需要新的选择,甚至更多地考虑到有许多体外潜在的分子还不能用于猫。需要更多的研究将体外抗真菌药敏试验结果与因孢子菌病治疗的猫的结果联系起来。本文将简要讨论抗真菌药物和治疗方案,以及治疗失败的决定因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances and challenges in the management of feline sporotrichosis

The domestic cat is the most susceptible host to Sporothrix infection, developing severe clinical forms. Few effective antifungal agents are available for treating feline sporotrichosis, and cases of treatment failure are common. Treatment success depends on cat health status, therapy-related factors, as well as social/economic issues, but it is mainly contingent upon the host–fungus interaction. The owner's adherence is critical and should be reinforced throughout the treatment to increase the chances of a successful outcome. The antifungal agents described for feline sporotrichosis are most often used in monotherapy regimens. Due to cases in which the treatment with itraconazole failed, the use of antifungal agents in combination should be considered to achieve synergy. The combination of itraconazole and potassium iodide represents an important option for the treatment of naïve cats presenting multiple cutaneous lesions, nasal mucosal lesions and/or respiratory signs, as well as for refractory cases. However, the therapeutic options for unsuccessfully treated cases are scarce. Therefore new options are needed, even more taking into account that there are many in vitro potential molecules not available for use in cats yet. More studies are necessary to correlate in vitro antifungal susceptibility tests results and the outcome of cats treated due to sporotrichosis. This review will briefly discuss both the antifungal drugs and treatment protocols used in cats with sporotrichosis, as well as the determinants of treatment failure.

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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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