回顾性评估体内放射性碘暴露引起的细胞遗传效应:27年跟踪研究

IF 1.7 4区 生物学 Q4 CELL BIOLOGY
Cytogenetic and Genome Research Pub Date : 2023-01-01 Epub Date: 2023-08-12 DOI:10.1159/000533396
Gordon K Livingston, Terri L Ryan, Maria B Escalona, Alvis E Foster, Adayabalam S Balajee
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引用次数: 0

摘要

放射性碘(131I)被广泛用于治疗甲状腺机能亢进症和分化型甲状腺癌的有效消融治疗。放射性碘(131I)占目前核医学领域所用疗法的90%。1992年至1994年期间,一名男性甲状腺乳头状癌患者在26个月内接受了两轮放射性碘治疗,我们在此报告对该患者27年的长期细胞遗传学随访研究结果。自 1992 年首次使用放射性碘以来,对该患者进行了全面的细胞遗传学随访研究,包括细胞分裂受阻微核检测、双中心染色体检测、全基因组易位和倒位。本研究中检测到的微核(0.006/细胞)和双中心染色体(0.008/细胞)的频率与 2019 年早些时候报告的频率极为相似。mFISH 分析在 8.6% 的细胞中检测到染色体畸变,表现为不平衡易位和平衡易位。此外,在分析的 500 个细胞中,有 2 个细胞观察到涉及染色体 14p;15q 的克隆易位。在检测的 500 个细胞中,有一个细胞出现了复杂易位(涉及 9、10 和 16 号染色体),另外还有 5 个细胞出现了染色体重排。总之,我们的研究表明,过去的放射性碘暴露会导致长期的染色体损伤,易位的持续存在可用于回顾性生物模拟和监测放射性碘暴露者淋巴细胞中的染色体不稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retrospective Evaluation of Cytogenetic Effects Induced by Internal Radioiodine Exposure: A 27-Year Follow-Up Study.

Radioiodine (131I) is widely used in the treatment of hyperthyroidism and as an effective ablative therapy for differentiated thyroid cancer. Radioiodine (131I) constitutes 90% of the currently used therapies in the field of nuclear medicine. Here, we report the cytogenetic findings of a long-term follow-up study of 27 years on a male patient who received two rounds of radioiodine treatment within a span of 26 months between 1992 and 1994 for his papillary thyroid cancer. A comprehensive cytogenetic follow-up study utilizing cytokinesis blocked micronucleus assay, dicentric chromosome assay, genome wide translocations and inversions was initiated on this patient since the first administration of radioiodine in 1992. Frequencies of micronuclei (0.006/cell) and dicentric chromosomes (0.008/cell) detected in the current study were grossly similar to that reported earlier in 2019. The mFISH analysis detected chromosome aberrations in 8.6% of the cells in the form of both unbalanced and balanced translocations. Additionally, a clonal translocation involving chromosomes 14p; 15q was observed in 2 of the 500 cells analyzed. Out of the 500 cells examined, one cell showed a complex translocation (involving chromosomes 9, 10, and 16) besides 5 other chromosome rearrangements. Collectively, our study indicates that the past radioiodine exposure results in long-lasting chromosome damage and that the persistence of translocations can be useful for both retrospective biodosimetry and for monitoring chromosome instability in the lymphocytes of radioiodine exposed individuals.

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来源期刊
Cytogenetic and Genome Research
Cytogenetic and Genome Research 生物-细胞生物学
CiteScore
3.10
自引率
5.90%
发文量
25
审稿时长
1 months
期刊介绍: During the last decades, ''Cytogenetic and Genome Research'' has been the leading forum for original reports and reviews in human and animal cytogenetics, including molecular, clinical and comparative cytogenetics. In recent years, most of its papers have centered on genome research, including gene cloning and sequencing, gene mapping, gene regulation and expression, cancer genetics, comparative genetics, gene linkage and related areas. The journal also publishes key papers on chromosome aberrations in somatic, meiotic and malignant cells. Its scope has expanded to include studies on invertebrate and plant cytogenetics and genomics. Also featured are the vast majority of the reports of the International Workshops on Human Chromosome Mapping, the reports of international human and animal chromosome nomenclature committees, and proceedings of the American and European cytogenetic conferences and other events. In addition to regular issues, the journal has been publishing since 2002 a series of topical issues on a broad variety of themes from cytogenetic and genome research.
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