脑卒中后脑-心相互作用中的炎症反应和免疫调节。

IF 3.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Therapeutics Pub Date : 2022-01-01 DOI:10.1155/2022/2406122

Lihua Zou, Ruquan Han

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引用次数: 2

摘要

脑心综合征(CCS)是脑卒中后继发性心肌损伤之一。脑心综合征预后差，死亡率高。了解脑-心相互作用的机制可能对临床治疗CCS的病理改变至关重要。越来越多的证据表明，中风后的炎症反应参与了大脑-心脏的相互作用。中风引起的全身炎症反应综合征(Systemic inflammatory response syndrome, SIRS)可直接损伤心肌细胞，其中炎症反应、氧化应激、心脏交感/副交感神经功能障碍和脾免疫调节之间的相互作用也可能是关键的病理生理因素。本文综述了脑卒中后炎症反应和免疫调节在脑-心相互作用中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke.

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Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke.

Cerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke. Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding the mechanism of the brain-heart interaction may be crucial for clinical treatment of pathological changes in CCS. Accumulating evidence suggests that the inflammatory response is involved in the brain-heart interaction after stroke. Systemic inflammatory response syndrome (SIRS) evoked by stroke may injure myocardial cells directly, in which the interplay between inflammatory response, oxidative stress, cardiac sympathetic/parasympathetic dysfunction, and splenic immunoregulation may be also the key pathophysiology factor. This review article summarizes the current understanding of inflammatory response and immune regulation in brain-heart interaction after stroke.

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来源期刊

Cardiovascular Therapeutics 医学-心血管系统

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Cardiovascular Therapeutics (formerly Cardiovascular Drug Reviews) is a peer-reviewed, Open Access journal that publishes original research and review articles focusing on cardiovascular and clinical pharmacology, as well as clinical trials of new cardiovascular therapies. Articles on translational research, pharmacogenomics and personalized medicine, device, gene and cell therapies, and pharmacoepidemiology are also encouraged. Subject areas include (but are by no means limited to): Acute coronary syndrome Arrhythmias Atherosclerosis Basic cardiac electrophysiology Cardiac catheterization Cardiac remodeling Coagulation and thrombosis Diabetic cardiovascular disease Heart failure (systolic HF, HFrEF, diastolic HF, HFpEF) Hyperlipidemia Hypertension Ischemic heart disease Vascular biology Ventricular assist devices Molecular cardio-biology Myocardial regeneration Lipoprotein metabolism Radial artery access Percutaneous coronary intervention Transcatheter aortic and mitral valve replacement.