中性粒细胞与淋巴细胞比率作为妊娠期间不宁腿综合征炎症的标志。

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Mustafa Karadeniz, Merve Hazal Ser, Mecbure Nalbantoglu, Feray Bolukbasi Tumay, Nevin Yilmaz, Serdar Acikgoz, Gulcin Benbir Senel
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引用次数: 2

摘要

目的:妊娠被认为是不宁腿综合征/威利斯-艾伯姆病(RLS/WED)的独立危险因素。中性粒细胞与淋巴细胞比值(NLR)最近在RLS/WED的病理生理中被报道。在本报告中,我们调查了妊娠期RLS/WED与NLR水平之间的关系。方法:纳入268例常规产前检查的孕妇;148名女性有RLS/WED, 120名女性无RLS/WED为对照组。对所有参与者进行预先编制的问卷调查,问卷内容包括人口统计学特征、习惯行为、详细病史和有关RLS/WED的问题,包括疾病持续时间、严重程度和家族史。对所有参与者进行全血细胞计数、NLR、空腹血糖、尿素氮、肌酐、铁蛋白和总铁结合能力的实验室调查。结果:有RLS/WED的孕妇NLR明显高于无RLS/WED的孕妇(3.9±0.9 vs 3.5±1.1,p=0.039)。吸烟在患有RLS/WED的孕妇中也更为常见(p=0.022)。即使在调整了年龄、BMI和吸烟等因素后,NLR也随着妊娠期的延长而显著增加(p=0.035)。RLS/WED孕妇的NLR增高在妊娠晚期尤为突出,但差异不显著。结论:这些结果可能表明,NLR增加所表现出的炎症增加,可能在一定程度上导致妊娠期RLS/WED患病率升高,特别是在妊娠后期(表2,图1,参考文献34)。关键词:中性粒细胞与淋巴细胞比例,不宁腿综合征/Willis-Ekbom病,妊娠,炎症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neutrophil‑to‑lymphocyte ratio as a marker of inflammation in restless legs syndrome during pregnancy.
PURPOSE The pregnancy is accepted as an independent risk factor for restless legs syndrome/Willis-Ekbom disease (RLS/WED). The neutrophil-to-lymphocyte ratio (NLR) was recently reported in the pathophysiology of RLS/WED. In this report, we investigated the relationship between the presence of RLS/WED and the levels of NLR in pregnancy. METHODS We included 268 pregnant women attending routine prenatal visits; 148 women had RLS/WED, and 120 women without RLS/WED were the control group. A pre-formed questionnaire was administered to all participants regarding demographic characteristics, habitual behaviors, detailed medical history and questions about RLS/WED including disease duration, severity, and family history. Laboratory investigations were performed in all participants regarding the complete blood count, NLR, fasting blood glucose, blood urea nitrogen, creatinine, ferritin, and total iron binding capacity. RESULTS NLR was significantly higher in pregnant women with RLS/WED as compared to those without it (3.9±0.9 versus 3.5±1.1, p=0.039). Smoking was also significantly more common in pregnant women with RLS/WED (p=0.022). NLR significantly increased as the gestational period progressed, even after the adjustments for age, BMI, and smoking (p=0.035). Higher NLR in pregnant women with RLS/WED was especially prominent in the 3rd trimester, although the difference was not significant. CONCLUSION These results may suggest that an increased inflammation demonstrated by the increased NLR, may, in part, play a role in higher prevalence of RLS/WED in pregnancy, especially in late gestational weeks (Tab. 2, Fig. 1, Ref. 34). Text in PDF www.elis.sk Keywords: neutrophil-to-lymphocyte ratio, restless legs syndrome/Willis-Ekbom disease, pregnancy, inflammation.
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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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