患病朝圣者的呼吸道病原体以及在朝觐期间使用即时护理快速分子诊断工具的潜在好处。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Van-Thuan Hoang, Thi-Loi Dao, Tran Duc Anh Ly, Tassadit Drali, Saber Yezli, Philippe Parola, Vincent Pommier de Santi, Philippe Gautret
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引用次数: 2

摘要

我们调查了来自马赛的患病朝觐朝圣者的呼吸道病原体。我们还讨论了点护理(POC)快速分子诊断工具在这方面的潜在作用。采用标准化问卷收集临床资料。利用实时荧光定量PCR对旅行期间出现症状时获得的呼吸道样本进行了甲型和乙型流感病毒、人鼻病毒和人冠状病毒、金黄色葡萄球菌、肺炎链球菌、流感嗜血杆菌和肺炎克雷伯菌的检测。共纳入207名参与者。咳嗽、咳痰、鼻炎和喉咙痛是最常见的呼吸道症状,其次是失声和呼吸困难。38.7%和25.1%的朝圣者分别报告有发烧和流感样症状。59.4%的朝圣者使用了抗生素。最常见的病原体是鼻病毒(40.6%),其次是金黄色葡萄球菌(35.8%)和流感嗜血杆菌(30.4%)。在28.5%的参与者中发现了病毒和细菌的双重感染。25.1%的朝圣者呼吸道细菌检测呈阳性,未接受抗生素治疗。在朝觐朝圣的背景下,重要的是要发现可以通过适当治疗轻松控制的感染,以及那些可能影响预后、需要住院治疗的感染。POC快速分子诊断工具可用于小型朝觐医疗任务的患者管理,并使朝觐朝圣者的抗生素消费合理化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Respiratory pathogens among ill pilgrims and the potential benefit of using point-of-care rapid molecular diagnostic tools during the Hajj.

We investigated respiratory pathogens among ill Hajj pilgrims from Marseille. We also discuss the potential role of point-of-care (POC) rapid molecular diagnostic tools for this purpose. Clinical data were collected using a standardised questionnaire. Influenza A and B viruses, human rhinovirus and human coronaviruses, Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Klebsiella pneumoniae were investigated using real-time PCR in respiratory samples obtained during travel, at the onset of symptoms. 207 participants were included. A cough, expectoration, rhinitis and a sore throat were the most frequent respiratory symptoms, followed by loss of voice and dyspnoea. 38.7% and 25.1% of pilgrims reported a fever and influenza-like symptoms, respectively. 59.4% pilgrims received antibiotics. Rhinovirus (40.6%) was the most frequent pathogen, followed by S. aureus (35.8%) and H. influenzae (30.4%). Virus and bacteria co-infections were identified in 28.5% of participants. 25.1% pilgrims who were positive for respiratory bacteria did not receive antibiotic treatment. In the context of the Hajj pilgrimage, it is important to detect infections that can be easily managed with appropriate treatment, and those that can affect prognosis, requiring hospitalisation. POC rapid molecular diagnostic tools could be used for patient management at small Hajj medical missions and to rationalise antibiotic consumption among Hajj pilgrims.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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