纤维蛋白原在产后出血中的作用

IF 4.7 3区医学 Q1 ANESTHESIOLOGY

Best Practice & Research-Clinical Anaesthesiology Pub Date : 2022-12-01 DOI:10.1016/j.bpa.2022.10.002

Tim Vermeulen MD (Anesthesiology Trainee) , Marc Van de Velde MD, PhD, EDRA, FESAIC (Professor)

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引用次数: 3

摘要

产后出血(PPH)是全世界孕产妇死亡的主要原因(世卫组织)，每年造成近6万人死亡。妊娠是一个血栓形成前的状态，几个凝血因子的水平增加，以保护分娩期间的出血问题的产妇。纤维蛋白原在凝血和出血中有重要作用。研究指出，分娩前纤维蛋白原水平较低，以及PPH开始时纤维蛋白原水平较低，可预测大出血。早期，目标导向的纤维蛋白原浓缩治疗可能对严重PPH患者亚组非常有用。本文就目前关于PPH中纤维蛋白原的研究进展进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of fibrinogen in postpartum hemorrhage

Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide (WHO), with almost 60000 deaths annually. Pregnancy is a prothrombotic state with increased levels of several coagulation factors to protect the parturient from bleeding problems during delivery. Fibrinogen has a significant role in coagulation and bleeding. Studies have pointed out that lower fibrinogen levels before delivery, but also at the initiation of PPH, are predictive of major hemorrhage. Early, the goal-directed fibrinogen concentrate therapy might be very useful in a subgroup of patients with serious PPH. This review aims to summarize the current literature on fibrinogen during PPH.

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Best Practice & Research-Clinical Anaesthesiology ANESTHESIOLOGY-

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审稿时长

36 days