同一患者使用相同的血液滤过器进行稀释前和稀释后在线血液滤过的去除效果。

IF 1.1 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2022-12-14 DOI:10.1007/s10047-022-01379-4
Kazuyoshi Okada, Hiroyuki Michiwaki, Hiroaki Mori, Manabu Tashiro, Tomoko Inoue, Hisato Shima, Koji Ohshima, Jun Minakuchi, Shu Kawashima
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引用次数: 1

摘要

肾替代治疗的在线血液滤过(OHDF)有两种模式:预稀释(pre-OHDF)和稀释后血液滤过(post-OHDF)。为了阐明两种模式之间的确切差异,在同一患者中使用相同的聚砜血液滤过器进行了临床研究。8例患者接受ABH™-22PA治疗6周:3周ohdf前治疗(替代量分别为24、36和48 L), 3周ohdf后治疗(替代量分别为6、8和10 L)。评估尿素、尿酸(UA)、肌酐(CRE)、无机磷(iP)、β -2微球蛋白(β2-MG)和α -1微球蛋白(α1-MG)的降低率。通过分析废透析液,评估β2-MG、α1-MG和白蛋白的去除率。记录不良事件(ae)和器械故障的类型和数量。尿素、UA、CRE、iP和β2-MG的还原率在所有条件下具有可比性,而α1-MG的还原率在ohdf后略高于ohdf前。最大取代体积时α - 1- mg和白蛋白的去除率显著高于最小取代体积时。然而,α - 1- mg去除量除以白蛋白水平得到的选择性去除指数,在ohdf前倾向于略高于后。两种模式下均未发生与设备相关的ae或设备故障。用高敏c反应蛋白和白细胞介素-6来评估炎症反应,两组间无显著差异。本研究提供了ABH-22PA在ohdf前后应用的去除性能和安全性数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Removal performance of pre- and post-dilution online hemodiafiltration using identical hemodiafilters in the same patients.

Online hemodiafiltration (OHDF) for renal replacement therapy has two modes: pre- (pre-OHDF) and post-dilution OHDF (post-OHDF). To elucidate the precise differences between the two modes, a clinical study was performed using the same polysulfone hemodiafilters in the same patients. Eight patients were treated with ABH-22PA for 6 weeks: 3 weeks of pre-OHDF (with substitution volumes of 24, 36, and 48 L) and 3 weeks of post-OHDF (6, 8, and 10 L). The reduction ratios of urea, uric acid (UA), creatinine (CRE), inorganic phosphorus (iP), beta-2-microglobulin (β2-MG), and alpha-1-microglobulin (α1-MG) were evaluated. The removal amounts of β2-MG, α1-MG, and albumin were also evaluated by analyzing the spent dialysis fluids. The types and numbers of adverse events (AEs) and device malfunctions were recorded. The reduction ratios of urea, UA, CRE, iP, and β2-MG were comparable among all conditions, while that of α1-MG tended to be slightly higher in post-OHDF than in pre-OHDF. The removal amounts of α1-MG and albumin in pre-OHDF and post-OHDF were significantly greater with the maximum substitution volume than with the minimum volume. However, the selective removal indices, which were obtained by dividing the amount of α1-MG removed by the albumin level, tended to be slightly higher in pre- than in post-OHDF. No device-related AEs or device malfunctions occurred in either mode. No significant differences in inflammatory responses, evaluated by high-sensitivity C-reactive protein and interleukin-6, were observed. This study provides removal performance and safety data regarding the application of ABH-22PA for pre- and post-OHDF.

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来源期刊
Journal of Artificial Organs
Journal of Artificial Organs 医学-工程:生物医学
CiteScore
2.80
自引率
15.40%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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