骨关节炎的自然疗法。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Alice Grigore, Virginia Vulturescu
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引用次数: 0

摘要

骨关节炎(OA)是世界范围内最常见的关节疾病,其发病率的上升与肥胖和久坐等因素有关。在分子水平上,它被认为是一种导致关节软骨破坏的炎症性疾病。有效的治疗方法来结束关节炎的退行性过程仍然是难以捉摸的,大多数治疗工具防止进展或减轻症状。目前,治疗OA的药物可用于口服、局部或关节内(IA)治疗,包括镇痛药、非甾体抗炎药、皮质类固醇和透明质酸。与传统的口服给药相比,IA治疗在生物利用度、疗效和毒性方面具有多重优势。本文旨在研究中药在OA治疗中的潜在有益作用,并开辟新的研究前景。口服或局部使用的草药显示出可能与OA有益作用相关的药理学特性,主要是抗炎和抗氧化作用。关于植物提取物/化合物的IA注射的研究很少,也没有与临床已经使用的药物的任何组合有关。设计具有更高生物利用度的天然药物配方,安全,没有副作用,并经过专门测试,将是药用植物研究的一个加分项,也是临床的一个新奇之处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Natural Approach in Osteoarthritis Therapy.

Osteoarthritis (OA) is the most common joint disease worldwide, and its rising prevalence is supported by factors such as obesity and sedentariness. At the molecular level, it is considered an inflammatory disease that leads to the destruction of articular cartilage. Effective therapy to end the degenerative process of arthritis remains elusive, and most therapeutic tools prevent the progress or alleviate the symptoms. By now, medicines for OA are available for oral, topical, or intra-articular (IA) therapy and include analgesics, nonsteroidal anti-inflammatory drugs, corticosteroids, and hyaluronic acid. Compared with conventional oral administration, IA therapy has multiple advantages in terms of bioavailability, efficacy, and toxicity. This review aims to study the underlying beneficial effects of herbal medicine in OA therapy and to open new research perspectives. Herbal medicine administered orally or topically exhibits pharmacological properties that could be relevant for their beneficial effect in OA, mainly anti-inflammatory and antioxidant effects. There are few studies regarding IA injections of plant extracts/ compounds and none related to any combination with agents already used in the clinic. Designing natural pharmaceutical formulations with increased bioavailability that are safe, lack side effects, and are specifically tested, would be a plus for research on medicinal plants and a novelty for the clinic.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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