心力衰竭中的心脏纤维化:关注无创诊断和新兴治疗策略

IF 8.7 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Susana Ravassa , Begoña López , Thomas A. Treibel , Gorka San José , Blanca Losada-Fuentenebro , Leire Tapia , Antoni Bayés-Genís , Javier Díez , Arantxa González
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引用次数: 1

摘要

心力衰竭是全球死亡和住院的主要原因。胶原纤维过度沉积导致的心脏纤维化是心力衰竭各种疾病的常见特征。最终,在长期的心脏纤维化中,无论是修复性的还是反应性的,都会导致心力衰竭的发展和进展,并与不良的临床结果有关。尽管如此,缺乏特定的心脏抗纤维化疗法,这使得心脏纤维化成为一种急需满足的医疗需求。在这种情况下,需要更好的患者表型来表征心脏纤维化的异质性特征,以推进其个性化管理。在这篇综述中,我们将描述心力衰竭中与心脏纤维化相关的不同表型,并将重点关注成像技术和循环生物标志物对这种疾病的非侵入性表征和表型以及跟踪其临床影响的潜在有用性。我们还将概述现有心力衰竭和非心力衰竭药物的心脏抗纤维化作用,并讨论临床前开发中针对不同水平的心脏成纤维细胞活化以及针对额外的心外过程的潜在策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis, resulting from the excessive deposition of collagen fibers, is a common feature across the spectrum of conditions converging in heart failure. Eventually, either reparative or reactive in nature, in the long-term cardiac fibrosis contributes to heart failure development and progression and is associated with poor clinical outcomes. Despite this, specific cardiac antifibrotic therapies are lacking, making cardiac fibrosis an urgent unmet medical need. In this context, a better patient phenotyping is needed to characterize the heterogenous features of cardiac fibrosis to advance toward its personalized management. In this review, we will describe the different phenotypes associated with cardiac fibrosis in heart failure and we will focus on the potential usefulness of imaging techniques and circulating biomarkers for the non-invasive characterization and phenotyping of this condition and for tracking its clinical impact. We will also recapitulate the cardiac antifibrotic effects of existing heart failure and non-heart failure drugs and we will discuss potential strategies under preclinical development targeting the activation of cardiac fibroblasts at different levels, as well as targeting additional extracardiac processes.

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来源期刊
Molecular Aspects of Medicine
Molecular Aspects of Medicine 医学-生化与分子生物学
CiteScore
18.20
自引率
0.00%
发文量
85
审稿时长
55 days
期刊介绍: Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.
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