探索多酚类化合物的抗癌潜力:近五年专利综述。

IF 2.5 4区 医学 Q3 ONCOLOGY
Nitin Gupta, Shaloo Singh, Divya Chauhan, Ruchi Srivastava, Vipendra Kumar Singh
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引用次数: 3

摘要

背景:植物中大量发现的多酚类物质对肿瘤细胞具有多种抗癌作用,包括血管生成、转移、抗增殖、炎症和凋亡。近年来,世界范围内已经发现了许多具有抗癌活性的新型多酚类化合物,其中很少有希望通过干扰癌症的发生、促进和进展来治愈或抑制癌症的生长。目的:这篇小型综述旨在全面调查全球专利中披露的多酚类抗癌药物的信息,并讨论它们作为临床抗癌药物开发的可能性。方法:根据多酚类化合物的作用机制,对其抗癌特性进行综述。PubMed、Google Patents和SciDirect数据库被用于编制本研究。结果:近五年来,全球专利中发现了多种抗癌多酚,其作用模式指出了细胞骨架损伤、阻滞细胞周期、抑制激酶和肿瘤抑制蛋白的表达。结论:许多新发现的多酚类物质在体外和体内均显示出良好的抗癌潜力,少数抗癌多酚类物质可抑制多种人类癌细胞的生长。此外,我们还概述了近五年来有关多酚抗癌潜力的专利申请。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Anticancer Potentials of Polyphenols: A Comprehensive Review of Patents in the Last Five Years.

Background: Polyphenols found abundantly in plants exhibit various anti-carcinogenic effects on tumor cells, including angiogenesis, metastasis, anti-proliferating agents, inflammation, and apoptosis. In recent years, many novel polyphenolic compounds with anticancer activity have been identified worldwide, and few of them are promising anticancer drugs to cure or inhibit cancer growth by interfering with cancer initiation, promotion, and progression.

Objectives: This mini-review aims to provide a comprehensive survey of the information about polyphenolic anticancer drugs disclosed in worldwide patents and discuss their possibility of developing as drugs used as anticancer drugs in clinical settings.

Methods: In the present mini-review, we have revealed the anticancer properties of polyphenols presented according to their mechanisms of action. PubMed, Google Patents, and SciDirect databases were used to compile the present study.

Results: In the last five years, various anticancer polyphenols were revealed in worldwide patents in the last decades, and their mode of action pointed out cytoskeletal damage, arresting cell cycle, inhibiting kinase, and tumor suppressor protein expression.

Conclusion: Many newly found polyphenols display a promising anticancer potential both in vitro and in vivo, and a few anticancer polyphenols act to inhibit the growth of various human cancer cells. Also, we have given an overview of patents filed in the last five years related to the anticancer potentials of polyphenols.

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来源期刊
CiteScore
4.50
自引率
7.10%
发文量
55
审稿时长
3 months
期刊介绍: Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.
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