类风湿关节炎的发病机制和治疗的新见解

Q1 Medicine
Shangyi Jin, Jiuliang Zhao, Mengtao Li, Xiaofeng Zeng
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引用次数: 3

摘要

在过去的几十年里,对类风湿关节炎(RA)发病机制的了解有了很大的提高。对类风湿性关节炎的细胞和分子机制的深入了解使得新的治疗靶点得以发现,并导致了生物制剂和靶向合成疾病改善抗风湿药物的发展。在治疗方法改进的同时,RA治疗策略的发展也大大改善了患者的预后。主要的变化包括制定疾病活动措施、制定从治疗到目标的原则以及增加对合并症的关注。合并症如心血管疾病的存在可能会增加RA患者的死亡率,影响他们的治疗策略并导致更糟糕的结果。因此,预防和管理某些高风险合并症在RA的长期治疗中变得越来越重要。在这项研究中,我们总结了关于类风湿关节炎及相关合并症的发病机制和治疗的新见解,特别关注2021年更新的美国风湿病学会(ACR) RA指南和2021年ACR会议上发表的关键报告。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

New insights into the pathogenesis and management of rheumatoid arthritis

New insights into the pathogenesis and management of rheumatoid arthritis

Over the past few decades, understanding of the pathogenesis of rheumatoid arthritis (RA) has improved substantially. Insights into the cellular and molecular mechanisms involved in RA have enabled the discovery of new therapeutic targets and led to the development of biologics and targeted synthetic disease-modifying antirheumatic drugs. In parallel with the improvement in therapies, the evolution of strategies in the management of RA has also contributed considerably to better outcomes in patients. Major changes include the development of disease activity measures, formulation of the treat-to-target principles as well as increased attention to comorbidities. The presence of comorbidities such as cardiovascular diseases may increase the mortality of RA patients, affect their treatment strategies and result in worse outcomes. Therefore, prevention and management of certain high-risk comorbidities have become increasingly important in the long-term treatment of RA. In this study, we summarized new insights into the pathogenesis and management of rheumatoid arthritis and associated comorbidities, with a special focus on the 2021 update of the American College of Rheumatology (ACR) guideline for RA and key reports presented at the 2021 ACR convergence.

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来源期刊
CiteScore
6.70
自引率
0.00%
发文量
195
审稿时长
35 weeks
期刊介绍: This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.
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