{"title":"肺腺癌患者血浆lncRNA CASC11与恶性肿瘤的相关性及lncRNA CASC11的预后价值","authors":"Xiaojuan Gu, Yanlin Zhang, Hao Xiong","doi":"10.2217/pme-2022-0104","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objective:</b> To study the connection between lncRNA <i>CASC11</i> plasma expression and clinical characteristics as well as prognoses of patients. <b>Methods:</b> Sixty lung adenocarcinoma (LUAD) patients and 60 healthy adults participated in this research. LncRNA <i>CASC11</i> expression was detected by quantitative real-time PCR and the relationships between lncRNA <i>CASC11</i> plasma expression and patient prognosis and clinical characteristics were analyzed. <b>Results:</b> LncRNA <i>CASC11</i> was highly expressed in LUAD tissues and plasma (p < 0.05). Receiver operating characteristic curve analysis indicated the diagnostic value of lncRNA <i>CASC11</i> in LUAD (p < 0.0001). Higher plasma lncRNA <i>CASC11</i> expression indicated worse patient prognoses (p < 0.05). Plasma lncRNA <i>CASC11</i> level was also closely related to tumor differentiation and tumor-node-metastasis stage (p < 0.05). <b>Conclusion:</b> Plasma lncRNA <i>CASC11</i> may be a potential biomarker for LUAD diagnosis and prognosis.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"20 2","pages":"167-173"},"PeriodicalIF":16.4000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Correlation between plasma lncRNA <i>CASC11</i> and malignancy in lung adenocarcinoma patients and the prognostic value of lncRNA <i>CASC11</i>.\",\"authors\":\"Xiaojuan Gu, Yanlin Zhang, Hao Xiong\",\"doi\":\"10.2217/pme-2022-0104\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objective:</b> To study the connection between lncRNA <i>CASC11</i> plasma expression and clinical characteristics as well as prognoses of patients. <b>Methods:</b> Sixty lung adenocarcinoma (LUAD) patients and 60 healthy adults participated in this research. LncRNA <i>CASC11</i> expression was detected by quantitative real-time PCR and the relationships between lncRNA <i>CASC11</i> plasma expression and patient prognosis and clinical characteristics were analyzed. <b>Results:</b> LncRNA <i>CASC11</i> was highly expressed in LUAD tissues and plasma (p < 0.05). Receiver operating characteristic curve analysis indicated the diagnostic value of lncRNA <i>CASC11</i> in LUAD (p < 0.0001). Higher plasma lncRNA <i>CASC11</i> expression indicated worse patient prognoses (p < 0.05). Plasma lncRNA <i>CASC11</i> level was also closely related to tumor differentiation and tumor-node-metastasis stage (p < 0.05). <b>Conclusion:</b> Plasma lncRNA <i>CASC11</i> may be a potential biomarker for LUAD diagnosis and prognosis.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":\"20 2\",\"pages\":\"167-173\"},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2217/pme-2022-0104\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/pme-2022-0104","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Correlation between plasma lncRNA CASC11 and malignancy in lung adenocarcinoma patients and the prognostic value of lncRNA CASC11.
Objective: To study the connection between lncRNA CASC11 plasma expression and clinical characteristics as well as prognoses of patients. Methods: Sixty lung adenocarcinoma (LUAD) patients and 60 healthy adults participated in this research. LncRNA CASC11 expression was detected by quantitative real-time PCR and the relationships between lncRNA CASC11 plasma expression and patient prognosis and clinical characteristics were analyzed. Results: LncRNA CASC11 was highly expressed in LUAD tissues and plasma (p < 0.05). Receiver operating characteristic curve analysis indicated the diagnostic value of lncRNA CASC11 in LUAD (p < 0.0001). Higher plasma lncRNA CASC11 expression indicated worse patient prognoses (p < 0.05). Plasma lncRNA CASC11 level was also closely related to tumor differentiation and tumor-node-metastasis stage (p < 0.05). Conclusion: Plasma lncRNA CASC11 may be a potential biomarker for LUAD diagnosis and prognosis.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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