子宫内囊胚的存在通过上调溶酶体蛋白稳态的活性，促进腔内上皮的转化，以利于植入。

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2024-01-01 Epub Date: 2023-08-22 DOI:10.1080/15548627.2023.2247747

Peike Wang, Shuailin Du, Chuanhui Guo, Zhangli Ni, Ziying Huang, Na Deng, Haili Bao, Wenbo Deng, Jinhua Lu, Shuangbo Kong, Hua Zhang, Haibin Wang

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引用次数: 0

摘要

缩写：缩写： ACTB：β肌动蛋白；AREG：两性胰蛋白酶；ATP6V0A4：ATPase, H+ transporting, lysosomal V0 subunit A4；Baf A1：巴非罗霉素 A1；BSA：牛血清白蛋白；CLDN1：claudin 1；CTSB：cathepsin B；DEGs：差异表达基因；E2：GATA2：GATA 结合蛋白 2；GLA：半乳糖苷酶，α；GO：基因本体；HBEGF：肝素结合 EGF 样生长因子；IGF1R：胰岛素样生长因子 1 受体；Ihh：Ihh：印度刺猬；ISH：原位杂交；LAMP1：溶酶体相关膜蛋白 1；LCM：激光捕获显微切割；Le：腔上皮细胞；LGMN：豆蛋白酶；LIF：白血病抑制因子；LIFR：LIF 受体α；MSH：原位杂交：MUC1：跨膜粘蛋白 1；P4：孕酮；PBS：磷酸盐缓冲盐水；PCA：主成分分析；PPT1：棕榈酰蛋白硫酯酶 1；PGR：PSP：假孕；PTGS2/COX2：前列腺素内过氧化物合成酶 2；qPCR：定量实时聚合酶链反应；SP：妊娠；TFEB：转录因子 EB。

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The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity.

Abbreviations: ACTB: actin beta; AREG: amphiregulin; ATP6V0A4: ATPase, H⁺ transporting, lysosomal V0 subunit A4; Baf A1: bafilomycin A₁; BSA: bovine serum albumin; CLDN1: claudin 1; CTSB: cathepsin B; DEGs: differentially expressed genes; E₂: 17β-estradiol; ESR: estrogen receptor; GATA2: GATA binding protein 2; GLA: galactosidase, alpha; GO: gene ontology; HBEGF: heparin-binding EGF-like growth factor; IGF1R: insulin-like growth factor 1 receptor; Ihh: Indian hedgehog; ISH: in situ hybridization; LAMP1: lysosomal-associated membrane protein 1; LCM: laser capture microdissection; Le: lumenal epithelium; LGMN: legumain; LIF: leukemia inhibitory factor; LIFR: LIF receptor alpha; MSX1: msh homeobox 1; MUC1: mucin 1, transmembrane; P₄: progesterone; PBS: phosphate-buffered saline; PCA: principal component analysis; PPT1: palmitoyl-protein thioesterase 1; PGR: progesterone receptor; PSP: pseudopregnancy; PTGS2/COX2: prostaglandin-endoperoxide synthase 2; qPCR: quantitative real-time polymerase chain reaction; SP: pregnancy; TFEB: transcription factor EB.

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.