脆性 X 综合征患者的先突变携带者母亲睡眠质量对健康的影响。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.1352/1944-7558-128.3.254

Robert S Dembo, Jinkuk Hong, Leann Smith DaWalt, Elizabeth M Berry-Kravis, Marsha R Mailick

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引用次数: 0

摘要

睡眠在支持身心健康方面发挥着不可或缺的作用，而睡眠困难在脆性 X 综合征（FXS）等发育障碍患者的母亲中很常见。本研究评估了 FMR1 预突变携带者母亲的睡眠质量对身体健康和抑郁的影响是否会因遗传风险因素（CGG 重复序列）而加剧。对于CGG重复序列处于突变中期范围（90-110个重复序列）的母亲来说，睡眠质量差会导致更多的身体健康问题，但对于CGG重复序列处于突变中期范围较低（<90个重复序列）或较高（>110个重复序列）的母亲来说，睡眠质量差不会导致更多的身体健康问题。研究还观察到睡眠质量差与母亲抑郁症状之间存在明显联系，但没有证据表明这种影响因遗传易感性水平的不同而不同。这项研究拓展了我们对 FXS 患者母亲睡眠质量影响个体差异的认识。

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Health Effects of Sleep Quality in Premutation Carrier Mothers of Individuals With Fragile X Syndrome.

Sleep plays an integral role in supporting well-being, and sleep difficulties are common in mothers of individuals with developmental disabilities, including fragile X syndrome (FXS). This study assessed whether the effects of sleep quality on physical health and depression are exacerbated by genetic risk factors (CGG repeats) in FMR1 premutation carrier mothers of individuals with FXS. Poor sleep quality predicted a greater number of physical health conditions for mothers with CGG repeats in the mid-premutation range (90-110 repeats), but not for those in the lower (< 90 repeats) or higher (> 110 repeats) ends of the range. A significant association between poor sleep quality and maternal depressive symptoms was also observed, but there was no evidence that this effect varied by level of genetic vulnerability. This research extends our understanding of individual differences in the effects of sleep quality among mothers of individuals with FXS.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.