Jose A Munoz, Anne-Catrin Uhlemann, Jonathan Barasch
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引用次数: 0
摘要
尿路感染（UTI）是最常见的泌尿生殖系统疾病。尿路感染会影响尿道、膀胱、输尿管和肾脏。在美国，共有 13.3% 的女性、2.3% 的男性和 3.4% 的儿童需要接受 UTI 治疗。传统上，膀胱（膀胱炎）和肾（肾盂肾炎）感染被认为是独立的。然而，这两种感染都会诱发宿主防御功能，而这些防御功能在整个泌尿道中是共享或协调的。在此，我们回顾了细菌滞留的化学和生物物理机制，这些机制限制了疾病的持续时间和严重程度。尿路细菌试图克服每一种防御机制，这使得对尿路感染自然史的描述变得更加复杂。
Innate Bacteriostatic Mechanisms Defend the Urinary Tract.
Urinary tract infection (UTI) is the most common type of urogenital disease. UTI affects the urethra, bladder, ureter, and kidney. A total of 13.3% of women, 2.3% of men, and 3.4% of children in the United States will require treatment for UTI. Traditionally, bladder (cystitis) and kidney (pyelonephritis) infections are considered independently. However, both infections induce host defenses that are either shared or coordinated across the urinary tract. Here, we review the chemical and biophysical mechanisms of bacteriostasis, which limit the duration and severity of the illness. Urinary bacteria attempt to overcome each of these defenses, complicating description of the natural history of UTI.
期刊介绍：
Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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