当前器官共享心脏分配系统联合网络面临的挑战。

IF 1.8 4区 医学 Q3 TRANSPLANTATION
Timothy A Gong, Shelley A Hall
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引用次数: 0

摘要

审查目的:修订后的美国心脏器官分配系统于2018年10月启动。在这篇综述中,我们总结了器官共享联合网络(UNOS)的政策,并描述了有意和无意的后果。最近的发现:尽管改变后发表的早期研究表明,移植后的存活率在6岁时下降 月和1 今年,最近发表的随访时间较长的出版物已经证实,在调整后的模型和几个患者队列中,移植后的存活率相当。此外,新的分配将等待名单的总时间从112时间减少到39时间 天(P 摘要:随着下一个分配系统的制定,必须减少将临时机械支持作为仅用于列出目的的策略的使用,确定更明确地划分疾病严重程度的属性,对例外请求进行更大的监督,并解决对患有持久LVAD的患者的担忧。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Challenges with the current United Network for Organ Sharing heart allocation system.

Purpose of review: The revised United States heart organ allocation system was launched in October 2018. In this review, we summarize this United Network for Organ Sharing (UNOS) policy and describe intended and unintended consequences.

Recent findings: Although early studies published after the change suggested postheart transplant survival declined at 6 months and 1 year, recent publications with longer follow-up time have confirmed comparable posttransplant survival in adjusted models and several patient cohorts. Moreover, the new allocation decreased overall waitlist time from 112 to 39 days ( P  < 0.001). Mean ischemic time increased because of greater distances traveled to acquire donor hearts under broader sharing. Despite the intention to decrease exception requests by expanding the number of priority tiers to provide more granular risk stratification, ∼30% of patients remain waitlisted under exception status. Left-ventricular assist device (LVAD) implants are declining and the number of LVAD patients on the transplant list has decreased dramatically after the allocation system change.

Summary: As the next allocation system is developed, it is imperative to curtail the use of temporary mechanical support as a strategy solely for listing purposes, identify attributes that more clearly stratify the severity of illness, provide greater oversight of exception requests, and address concerns regarding patients with durable LVADs.

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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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