新城疫病毒作为呼吸道黏膜疫苗载体的优势和挑战。

IF 5.7 2区 医学 Q1 VIROLOGY
Rik L de Swart , George A Belov
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引用次数: 0

摘要

新城疫病毒(NDV)是一种具有未分段负链RNA基因组的禽类病原体。基因组修饰的容易性、呼吸道嗜性和哺乳动物的自我限制性复制等特性使新冠病毒成为疫苗开发的有吸引力的载体。针对多种人类和动物病原体的实验性新冠病毒疫苗引发了系统和粘膜免疫反应,在临床前动物研究中具有保护作用,但其实际疗效仍有待证明。直到最近,基于新冠病毒的疫苗针对严重急性呼吸系统综合征冠状病毒2型的首次临床试验结果才公布,这突出了需要克服的挑战,以充分发挥新冠病毒作为快速开发经济实惠和有效的粘膜疫苗平台的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advantages and challenges of Newcastle disease virus as a vector for respiratory mucosal vaccines

Newcastle disease virus (NDV) is an avian pathogen with an unsegmented negative-strand RNA genome. Properties such as the ease of genome modification, respiratory tract tropism, and self-limiting replication in mammals make NDV an attractive vector for vaccine development. Experimental NDV-based vaccines against multiple human and animal pathogens elicited both systemic and mucosal immune responses and were protective in preclinical animal studies, but their real-life efficacy remains to be demonstrated. Only recently, the first results of clinical trials of NDV-based vaccines against SARS-CoV-2 became available, highlighting the challenges that need to be overcome to fully realize the potential of NDV as a platform for the rapid development of economically affordable and effective mucosal vaccines.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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