2-脱氧- d-葡萄糖:一种杀死低氧肿瘤细胞、降低Covid-19氧依赖性和其他药理活性的新药物

IF 2.1 Q3 PHARMACOLOGY & PHARMACY

Advances in Pharmacological and Pharmaceutical Sciences Pub Date : 2023-01-01 DOI:10.1155/2023/9993386

Raman Singh, Vidushi Gupta, Antresh Kumar, Kuldeep Singh

{"title":"2-脱氧- d-葡萄糖:一种杀死低氧肿瘤细胞、降低Covid-19氧依赖性和其他药理活性的新药物","authors":"Raman Singh, Vidushi Gupta, Antresh Kumar, Kuldeep Singh","doi":"10.1155/2023/9993386","DOIUrl":null,"url":null,"abstract":"The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various pharmaceutical properties of 2-DG are discussed.","PeriodicalId":7369,"journal":{"name":"Advances in Pharmacological and Pharmaceutical Sciences","volume":"2023 ","pages":"9993386"},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998157/pdf/","citationCount":"1","resultStr":"{\"title\":\"2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities.\",\"authors\":\"Raman Singh, Vidushi Gupta, Antresh Kumar, Kuldeep Singh\",\"doi\":\"10.1155/2023/9993386\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various pharmaceutical properties of 2-DG are discussed.\",\"PeriodicalId\":7369,\"journal\":{\"name\":\"Advances in Pharmacological and Pharmaceutical Sciences\",\"volume\":\"2023 \",\"pages\":\"9993386\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998157/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Pharmacological and Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/9993386\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Pharmacological and Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/9993386","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 1

摘要

不可代谢的葡萄糖类似物2-脱氧-d -葡萄糖(2-DG)显示出有希望的药理活性，包括抑制癌细胞生长和n -糖基化。它已被用作糖酵解抑制剂和势能限制模拟剂，抑制病原体相关的分子模式。2-DG的放射性同位素衍生物有作为示踪剂的应用。最近，2-DG被用作抗covid -19药物，以降低补充氧气的需求。本文讨论了2-DG的各种药物性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities.

查看原文本刊更多论文

2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities.

The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various pharmaceutical properties of 2-DG are discussed.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advances in Pharmacological and Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-

CiteScore

4.30

自引率

3.60%

发文量

审稿时长

17 weeks