黑色素瘤的形态学方面和治疗选择:过去十年的叙述性综述。

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Andreea Cătălina Tinca, Andrada Raicea, Andreea Raluca Szőke, Iuliu Gabriel Cocuz, Mihaela Cornelia Şincu, Raluca Niculescu, Adrian Horaţiu Sabău, Maria Cătălina Popelea, Radu Florin Fruntelată, Ovidiu Simion Cotoi
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引用次数: 0

摘要

黑色素瘤是一种皮肤恶性癌症,发病率逐年上升。这种肿瘤具有很高的侵袭性以及侵袭和转移的可能性。已经确定了与这类肿瘤增殖相关的多种因素,如暴露于紫外线(UV)辐射和特定的遗传背景。从组织学和细胞学的角度来看,黑色素瘤中最常见的细胞是上皮样细胞或梭形细胞。为了确认肿瘤的诊断和黑素细胞的起源,使用了特异性和敏感的标志物。此外,对这种癌症行为的观察,包括其增殖特性,导致了多种疗法的发展,每种疗法都是诊断时病理阶段的特征。虽然手术是原位黑色素瘤最重要的治疗和治疗选择,但多年来化疗一直是晚期黑色素瘤的主要治疗方法。然而,最近,靶向治疗和免疫疗法改变了治疗方法。目前,多项研究正试图获得有关肿瘤微环境的进一步数据,并研究靶向特定分子如何改变患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.

Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.

Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.

Morphological aspects and therapeutic options in melanoma: a narrative review of the past decade.

Melanoma is a malignant cancer of the skin, the incidence of which has been increasing year by year. This neoplasm has high aggressivity as well as the potential for invasion and metastases. Multiple factors related to the proliferation of this type of tumor have been identified, such as exposure to ultraviolet (UV) radiation and specific genetic backgrounds. From a histological and cytological point of view, the most common cells that are found in melanoma are epithelioid or spindle cells. To confirm the diagnosis and the melanocytic origin of the tumor, specific and sensitive markers are used. Also, observation of the behavior of this cancer, including its proliferative properties, has led to the development of multiple therapies, each of which is characteristic of the pathological stage at the time of diagnosis. While surgery is the most important therapeutic and curative option in cases of melanoma in situ, chemotherapy has been the main treatment for advanced stages of melanoma for many years. However, recently, targeted therapy and immunotherapy have changed the approach to treatment. At present, multiple studies are attempting to obtain further data about the tumor microenvironment and investigating how targeting particular molecules can change the prognosis of patients.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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