蜂毒对多重耐药病原菌的化学成分及抑菌活性研究。

IF 1.5 3区 农林科学 Q2 VETERINARY SCIENCES
Tülin G Gökmen, Hatice Yazgan, Yıldız Özdemir, Sedat Sevin, Nevin Turut, Şifa Karahan, Funda Eşki, İbrahim Kıvrak, Osman Sezer, Armağan E Ütük
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引用次数: 1

摘要

蜂毒具有抗菌作用,是一种强大的天然产物。需要新的抗微生物药物的最重要领域之一是预防和控制多重耐药病原体。今天,在医院和卫生保健机构中用于治疗耐多药病原体感染的抗菌产品不足以防止定植和传播,需要新的产品。研究天然物质蜂毒对耐甲氧西林金黄色葡萄球菌、耐万古霉素粪肠球菌、耐碳青霉烯类大肠杆菌、耐碳青霉烯类肺炎克雷伯菌和耐碳青霉烯类鲍曼不动杆菌的抑菌作用。结果发现,多重耐药病原菌MIC90和MBC90值在6.25 ~ 12.5 μg/mL之间,1 ~ 24 h内细菌数量减少4 ~ 6 log。特别是,在50 μg/mL和100 μg/mL浓度下,耐万古霉素粪肠球菌分离物在第1小时内降低了6 log cfu/mL。蜂毒对细菌的有效抑制率表明,它可能是一种潜在的耐多药病原菌的抗菌药物。贡献:抗生素耐药病原体的治疗选择是兽医和人类医学领域的一个主要问题。我们在这项研究中发现了对这些药物的高抗菌作用,这是一种天然产品。蜂疗是一种流行于世界各地的治疗方法,在许多健康领域都有应用。蜂毒也是一种可以用作药物或消毒剂原料的产品,可以填补可用于对抗耐药细菌的天然产品空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chemical composition and antibacterial activity of bee venom against multi-drug resistant pathogens.

Chemical composition and antibacterial activity of bee venom against multi-drug resistant pathogens.

Chemical composition and antibacterial activity of bee venom against multi-drug resistant pathogens.

Bee venom with an antimicrobial effect is a powerful natural product. One of the most important areas where new antimicrobials are needed is in the prevention and control of multi-drug resistant pathogens. Today, antibacterial products used to treat multi-drug resistant pathogen infections in hospitals and healthcare facilities are insufficient to prevent colonisation and spread, and new products are needed. The aim of the study is to investigate the antibacterial effect of the bee venom (BV), a natural substance, on the species of Methicillin resistant Staphylococcus aureus, Vancomycin resistant Enterococcus faecalis, Carbapenem resistant Escherichia coli, Carbapenem resistant Klebsiella pneumoniae and Carbapenem resistant Acinetobacter baumannii. As a result of this study, it was found that MIC90 and MBC90 values ranged from 6.25 μg/mL - 12.5 μg/mL and numbers of bacteria decreased by 4-6 logs within 1-24 h for multi-drug resistant pathogens. In particular, Vancomycin resistant Enterococcus faecalis isolate decreased 6 log cfu/mL at 50 μg/mL and 100 μg/mL concentrations in the first hour. The effective bacterial inhibition rate of bee venom suggests that it could be a potential antibacterial agent for multi-drug resistant pathogens.Contribution: The treatment options of antibiotic-resistant pathogens are a major problem in both veterinary and human medicine fields. We have detected a high antibacterial effect against these agents in this bee venom study, which is a natural product. Apitherapy is a fashionable treatment method all over the world and is used in many areas of health. Bee venom is also a product that can be used as a drug or disinfectant raw material and can fill the natural product gap that can be used against resistant bacteria.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
13
审稿时长
16 weeks
期刊介绍: The Onderstepoort Journal of Veterinary Research, is the official publication of the Onderstepoort Veterinary Institute. While it considers submissions from any geographic region, its focus is on Africa and the infectious and parasitic diseases and disease vectors that affect livestock and wildlife on the continent.
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