瑞香花素G和H，抗hiv大环3,4-邻瑞香烷正酯。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2023-09-15 DOI:10.1007/s11418-023-01750-6

Lingjian Tan, Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Di Zhou, Ning Li, Li Huang, Chin-Ho Chen, Wei Li

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引用次数: 0

摘要

从长柄达芙妮中分离到具有特殊大环3,4-邻达芙妮烷正构酯结构的水仙花苷G(1)和H(2)。通过物理化学和光谱分析，结合甲基酯化、手性各向异性衍生化反应和仿生转化等合成方法确定了它们的结构。对化合物1和2及其甲酯1a和2a的抗hiv活性进行了评价，其中1a和2a的IC50值分别为1.08和1.17 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata

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Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata

Daphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated from Daphne pedunculata. Their structures were determined by physicochemical and spectroscopic analyses combined with synthetic methods, including methyl esterification, derivatization reaction using a chiral anisotropic agent, and biomimetic conversion. Compounds 1 and 2 along with their methyl esters 1a and 2a were evaluated for anti-HIV activity, among which 1a and 2a exhibited potent activity with IC₅₀ values of 1.08 and 1.17 μM, respectively.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.